Stadelmann, Katrin; Latshang, Tsogyal D.; Nussbaumer-Ochsner, Yvonne; Tarokh, Leila; Ulrich, Silvia; Kohler, Malcolm; Bloch, Konrad E.; Achermann, Peter (2014). Impact of Acetazolamide and CPAP on Cortical Activity in Obstructive Sleep Apnea Patients. PLoS ONE, 9(4), e93931. Public Library of Science 10.1371/journal.pone.0093931
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STUDY OBJECTIVES
1) To investigate the impact of acetazolamide, a drug commonly prescribed for altitude sickness, on cortical oscillations in patients with obstructive sleep apnea syndrome (OSAS). 2) To examine alterations in the sleep EEG after short-term discontinuation of continuous positive airway pressure (CPAP) therapy.
DESIGN
Data from two double-blind, placebo-controlled randomized cross-over design studies were analyzed.
SETTING
Polysomnographic recordings in sleep laboratory at 490 m and at moderate altitudes in the Swiss Alps: 1630 or 1860 m and 2590 m.
PATIENTS
Study 1: 39 OSAS patients. Study 2: 41 OSAS patients.
INTERVENTIONS
Study 1: OSAS patients withdrawn from treatment with CPAP. Study 2: OSAS patients treated with autoCPAP. Treatment with acetazolamide (500-750 mg) or placebo at moderate altitudes.
MEASUREMENTS AND RESULTS
An evening dose of 500 mg acetazolamide reduced slow-wave activity (SWA; approximately 10%) and increased spindle activity (approximately 10%) during non-REM sleep. In addition, alpha activity during wake after lights out was increased. An evening dose of 250 mg did not affect these cortical oscillations. Discontinuation of CPAP therapy revealed a reduction in SWA (5-10%) and increase in beta activity (approximately 25%).
CONCLUSIONS
The higher evening dose of 500 mg acetazolamide showed the "spectral fingerprint" of Benzodiazepines, while 250 mg acetazolamide had no impact on cortical oscillations. However, both doses had beneficial effects on oxygen saturation and sleep quality.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division |
UniBE Contributor: |
Tarokh, Leila |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Nicole Jansen |
Date Deposited: |
12 Sep 2014 16:39 |
Last Modified: |
05 Dec 2022 14:34 |
Publisher DOI: |
10.1371/journal.pone.0093931 |
PubMed ID: |
24710341 |
BORIS DOI: |
10.7892/boris.52416 |
URI: |
https://boris.unibe.ch/id/eprint/52416 |
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