Geuking, Markus B.; McCoy, Kathleen; Macpherson, Andrew J. (2013). Metabolites from intestinal microbes shape Treg. Cell research, 23(12), pp. 1339-1340. Nature Publishing Group 10.1038/cr.2013.125
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Intestinal bacterial metabolites are an important communication tool between the host immune system and the commensal microbiota to establish mutualism. In a recent paper published in Science, Wendy Garrett and her colleagues report an exciting role of the three most abundant microbial-derived short-chain fatty acids (SCFA), acetic acid, propionic acid and butyric acid, in colonic regulatory T cell (cTreg) homeostasis.