Conductier, Grégory; Brau, Frédéric; Viola, Angèle; Langlet, Fanny; Ramkumar, Navean; Dehouck, Bénédicte; Lemaire, Thibault; Chapot, Raphaël; Lucas, Laurianne; Rovère, Carole; Maitre, Priscilla; Hosseiny, Salma; Petit-Paitel, Agnès; Adamantidis, Antoine Roger; Lakaye, Bernard; Risold, Pierre-Yves; Prévot, Vincent; Meste, Olivier; Nahon, Jean-Louis and Guyon, Alice (2013). Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nature neuroscience, 16(7), pp. 845-847. Nature America 10.1038/nn.3401
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Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Adamantidis, Antoine Roger |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1097-6256 |
Publisher: |
Nature America |
Language: |
English |
Submitter: |
Valentina Rossetti |
Date Deposited: |
18 Jun 2014 16:00 |
Last Modified: |
05 Dec 2022 14:35 |
Publisher DOI: |
10.1038/nn.3401 |
PubMed ID: |
23708141 |
BORIS DOI: |
10.7892/boris.53878 |
URI: |
https://boris.unibe.ch/id/eprint/53878 |
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