Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats

Schmökel, Hugo; Weber, F. E.; Hurter, K.; Schense, J. C.; Seiler, Gabriela; Rytz, Ulrich; Spreng, David; Schawalder, Peter; Hubbell, J. (2005). Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. Journal of small animal practice, 46(1), pp. 17-21. Pergamon Press

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OBJECTIVES

To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis.

METHODS

A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft.

RESULTS

Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture nonunions treated in this manner.

CLINICAL SIGNIFICANCE

This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.

Interest & Impact

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5 Citations in Web of Science ®
6 Citations in Scopus

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