Chiquet-Ehrismann, Ruth; Orend, Gertraud; Chiquet, Matthias; Tucker, Richard P; Midwood, Kim S (2014). Tenascins in stem cell niches. Matrix biology, 37, pp. 112-123. Elsevier 10.1016/j.matbio.2014.01.007
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Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated. All of these features are of importance in stem cell niches where a precise regulation of growth versus differentiation has to be guaranteed. In this review we summarize the expression and possible functions of tenascins in neural, epithelial and osteogenic stem cell niches during normal development and organ turnover, in the hematopoietic and pro-inflammatory niche as well as in the metastatic niche during cancer progression.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics |
UniBE Contributor: |
Chiquet, Matthias |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0945-053X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
21 Nov 2014 10:42 |
Last Modified: |
05 Dec 2022 14:38 |
Publisher DOI: |
10.1016/j.matbio.2014.01.007 |
PubMed ID: |
24472737 |
Uncontrolled Keywords: |
Cancer, Development, Hematopoiesis, Inflammation, Stem cell niche, Tenascin |
BORIS DOI: |
10.7892/boris.60250 |
URI: |
https://boris.unibe.ch/id/eprint/60250 |
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