Werner, Jens; Hartwig, Werner; Hackert, Thilo; Kaiser, Heiko; Schmidt, Jan; Gebhard, Martha M; Büchler, Markus W; Klar, Ernst (2012). Multidrug strategies are effective in the treatment of severe experimental pancreatitis. Surgery, 151(3), pp. 372-81. New York, N.Y.: Elsevier 10.1016/j.surg.2011.07.041
Full text not available from this repository.Trypsinogen activation, oxygen radicals, cytokines, leukocyte infiltration, and pancreatic ischemia are important steps in the pathogenesis of necrotizing pancreatitis and associated systemic complications. Several drugs that inhibit those pathogenetic steps attenuated biochemical and histologic changes, while survival remained low. The aim of the present study was to evaluate the benefit of multidrug approaches compared to monotherapies on organ injury and survival in acute experimental pancreatitis in the rat model of retrograde bile injection combined with intravenous cerulein.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Kaiser, Heiko Andreas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0039-6060 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Jeannie Wurz |
Date Deposited: |
04 Oct 2013 14:19 |
Last Modified: |
02 Mar 2023 23:20 |
Publisher DOI: |
10.1016/j.surg.2011.07.041 |
PubMed ID: |
21982067 |
Web of Science ID: |
000301016500005 |
URI: |
https://boris.unibe.ch/id/eprint/6097 (FactScience: 210993) |
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