Dealing with damage: Plasma membrane repair mechanisms.

Draeger, Annette; Babiychuk, Eduard; Schönauer, Roman; Atanassoff, Alexander P.; Wolfmeier, Heidi Annemarie (2014). Dealing with damage: Plasma membrane repair mechanisms. Biochimie, 107(Part A), pp. 66-72. Elsevier Masson SAS 10.1016/j.biochi.2014.08.008

Text 1-s2.0-S0300908414002260-main.pdf - Submitted Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

Eukaryotic cells have developed repair mechanisms, which allow them to reseal their membrane in order to prevent the efflux of cytoplasmic constituents and the uncontrolled influx of calcium. After injury, the Ca(2+)-concentration gradient fulfils a dual function: it provides guidance cues for the repair machinery and directly activates the molecules, which have a repair function. Depending on the nature of injury, the morphology of the cell and the severity of injury, the membrane resealing can be effected by lysosomal exocytosis, microvesicle shedding or a combination of both. Likewise, exocytosis is often followed by the endocytic uptake of lesions. Additionally, since plasmalemmal resealing must be attempted, even after extensive injury in order to prevent cell lysis, the restoration of membrane integrity can be achieved by ceramide-driven invagination of the lipid bilayer, during which the cell is prepared for apoptotic disposal. Plasmalemmal injury can be contained by a surfeit of plasma membrane, which serves as a trap for toxic substances: either passively by an abundance of cellular protrusions, or actively by membrane blebbing.

Interest & Impact

Downloads

4 since deposited on 06 Jan 2015
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item