Miron, Richard; Wei, Lingfei; Bosshardt, Dieter; Buser, Daniel; Sculean, Anton; Zhang, Yufeng (2014). Effects of enamel matrix proteins in combination with a bovine-derived natural bone mineral for the repair of bone defects. Clinical oral investigations, 18(2), pp. 471-478. Springer 10.1007/s00784-013-0992-5
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OBJECTIVES
Previously, the use of enamel matrix derivative (EMD) in combination with a natural bone mineral (NBM) was able to stimulate periodontal ligament cell and osteoblast proliferation and differentiation. Despite widespread use of EMD for periodontal applications, the effects of EMD on bone regeneration are not well understood. The aim of the present study was to test the ability of EMD on bone regeneration in a rat femur defect model in combination with NBM.
MATERIALS AND METHODS
Twenty-seven rats were treated with either NBM or NBM + EMD and assigned to histological analysis at 2, 4, and 8 weeks. Defect morphology and mineralized bone were assessed by μCT. For descriptive histology, hematoxylin and eosin staining and Safranin O staining were performed.
RESULTS
Significantly more newly formed trabecular bone was observed at 4 weeks around the NBM particles precoated with EMD when compared with NBM particles alone. The drilled control group, in contrast, achieved minimal bone regeneration at all three time points (P < 0.05).
CONCLUSIONS
The present results may suggest that EMD has the ability to enhance the speed of new bone formation when combined with NBM particles in rat osseous defects.
CLINICAL RELEVANCE
These findings may provide additional clinical support for the combination of EMD with bone graft for the repair of osseous and periodontal intrabony defects.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology 04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology |
UniBE Contributor: |
Miron, Richard John, Bosshardt, Dieter, Buser, Daniel Albin, Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-6981 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
08 Jan 2015 10:16 |
Last Modified: |
02 Mar 2023 23:25 |
Publisher DOI: |
10.1007/s00784-013-0992-5 |
PubMed ID: |
23652357 |
BORIS DOI: |
10.7892/boris.61501 |
URI: |
https://boris.unibe.ch/id/eprint/61501 |
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