Response to LIVint-15-00100

Vinikoor, Michael J; Sinkala, Edford; Wandeler, Gilles; Chi, Benjamin H (2015). Response to LIVint-15-00100. Liver international, 35(8), p. 2060. Blackwell Munksgaard 10.1111/liv.12803

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Although AST-to-platelet ratio index (APRI) and FIB-4 have been compared with liver biopsy in patients with hepatitis C virus (HCV), hepatitis B virus (HBV), HIV/HCV co-infection, and HIV/HBV co-infection, Johannessen and Lemoine stress that they have not been validated in HIV mono-infected populations in SSA. However, this is unlikely to occur because liver biopsy does not play a role in HIV management and the procedure carries its own risks for complication. Clinicians using APRI and FIB-4 in this setting should be aware of this limitation and should interpret test results in the context of each patient's clinical scenario. This article is protected by copyright. All rights reserved.

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