Musshoff, F; Madea, B; Stüber, F; Stamer, U M (2010). Enantioselective determination of ondansetron and 8-hydroxyondansetron in human plasma from recovered surgery patients by liquid chromatography-tandem mass spectrometry. Journal of analytical toxicology, 34(9), pp. 581-6. Cary, N.C.: Oxford University Press 10.1093/jat/34.9.581
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A liquid chromatographic-mass spectrometric assay with atmospheric pressure chemical ionization for quantification of ondansetron and its main metabolite 8-hydroxyondansetron in human plasma was presented. The enantiomeric separation was achieved on a Chiralcel OD-R column containing cellulose tris-(3,5-dimethylphenylcarbamate). The validation data were within the required limits. The assay was successfully applied to authentic plasma samples. Quantitative results from postoperative patients receiving ondansetron demonstrated a great interindividual variability in postoperative plasma drug concentrations, the metabolites were not detected in their unconjugated form. A wide variation in the S-(+)-/R-(-)-ondansetron concentration ratio between 0.14 and 7.18 is indicative for a stereoselective disposition or metabolism. In further studies CYP2D6 and CYP3A4 genotype dependent metabolism of ondansetron enantiomers as well as of co-administered drugs and clinical efficacy of the medication should be tested.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Stüber, Frank, Stamer, Ulrike |
ISSN: |
0146-4760 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Jeannie Wurz |
Date Deposited: |
04 Oct 2013 14:08 |
Last Modified: |
09 Feb 2023 09:55 |
Publisher DOI: |
10.1093/jat/34.9.581 |
PubMed ID: |
21073811 |
Web of Science ID: |
000283891700008 |
BORIS DOI: |
10.7892/boris.644 |
URI: |
https://boris.unibe.ch/id/eprint/644 (FactScience: 200040) |
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