Lohri, Corinne; Schaltegger, Claudia S Hutzli; VAN DEN Broek, Maries; Wenger, Roland H; Ruegg, Curzio; Fink, Daniel; Fehr, Mathias K; Knuth, Alexander; Zweifel, Martin (2014). Neutrophil expression of ICAM1, CXCR1, and VEGFR1 in patients with breast cancer before and after adjuvant chemotherapy. Anticancer research, 34(9), pp. 4693-4699. International Inst. of Anticancer Research
Full text not available from this repository. (Request a copy)BACKGROUND
Distinct populations of neutrophils have been identified based on the expression of intercellular adhesion molecule 1 (ICAM1, CD54) and chemokine receptor 1 (CXCR1, interleukin 8 receptor α).
AIM
We analyzed the expression of vascular endothelial growth factor receptor 1 (VEGFR1), a physiological negative regulator of angiogenesis, on distinct populations of neutrophils from the blood of patients before and after adjuvant chemotherapy for breast cancer.
MATERIALS AND METHODS
Neutrophil populations were distinguished as reverse transmigrated (ICAM1(high)/CXCR1(low)), naïve (ICAM1(low)/CXCR1(high)), or tissue-resident neutrophils (ICAM1(low)/CXCR1(low)), and their VEGFR1 expression quantified.
RESULTS
Reverse transmigrated ICAM1(high)/CXCR1(low) neutrophilic granulocytes decreased significantly after chemotherapy and these were also the cells with highest mean fluorescence intensity for VEGFR1.
CONCLUSION
Chemotherapy mainly reduces the number of reverse transmigrated long-lived ICAM1(high)/CXCR1(low) VEGFR1-expressing neutrophils. The decrease of antiangiogenic VEGFR1 may have a potential impact on tumour angiogenesis in patients undergoing adjuvant chemotherapy.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Zweifel, Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0250-7005 |
Publisher: |
International Inst. of Anticancer Research |
Language: |
English |
Submitter: |
Marianne Zahn |
Date Deposited: |
13 Mar 2015 11:29 |
Last Modified: |
05 Dec 2022 14:42 |
PubMed ID: |
25202046 |
Uncontrolled Keywords: |
Adjuvant chemotherapy, breast cancer, chemokine receptor 1, intercellular adhesion molecule 1, neutrophilic granulocyte, tumor angiogenesis, vascular endothelial growth factor receptor 1 |
URI: |
https://boris.unibe.ch/id/eprint/64564 |
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