First outbreak of sleeping disease in Switzerland: disease signs and virus characterization.

Schmidt-Posthaus, Heike; Diserens, Nicolas; Jankowska Hjortaas, Monika; Knüsel, Ralph; Hirschi, Regula; Taksdal, Torunn (2014). First outbreak of sleeping disease in Switzerland: disease signs and virus characterization. Diseases of aquatic organisms, 111(2), pp. 165-171. Inter-Research 10.3354/dao02766

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Sleeping disease is a contagious disease mainly of freshwater farmed rainbow trout, caused by salmonid alphavirus (SAV) Subtype 2. Here we describe the first case in Switzerland. Pathological changes ranged from acute pancreas necrosis to more chronic lesions with complete loss of exocrine pancreas and simultaneous degenerative, inflammatory and regenerative heart and muscle lesions. The partial sequencing of SAV E2 and nsp3 genes placed the Swiss SAV variant within the Subtype 2 clustering together with freshwater isolates from UK and continental Europe. Although mortality stayed low, growth rates were significantly reduced, making the disease economically relevant.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)
UniBE Contributor:	Schmidt-Posthaus, Heike, Diserens, Nicolas, Knüsel, Ralph, Hirschi, Regula
Subjects:	600 Technology > 630 Agriculture
ISSN:	0177-5103
Publisher:	Inter-Research
Language:	English
Submitter:	Lucia Gugger-Raaflaub
Date Deposited:	23 Apr 2015 12:39
Last Modified:	02 Mar 2023 23:26
Publisher DOI:	10.3354/dao02766
PubMed ID:	25266904
Uncontrolled Keywords:	Sleeping disease; Salmonid alphavirus; SAV; Subtype 2; Pathology; Trout; Phylogenetic analysis
URI:	https://boris.unibe.ch/id/eprint/65475