Plasma Levels of MASP-1 and MASP-2 are Elevated in Type 1 Diabetes and Correlate with Glycaemic Control

Jenny, Lorenz; Ajjan, Ramzi; King, Rhodri; Thiel, Steffen; Schroeder, Verena (2015). Plasma Levels of MASP-1 and MASP-2 are Elevated in Type 1 Diabetes and Correlate with Glycaemic Control. Clinical and experimental immunology, 180(2), pp. 227-232. Blackwell Scientific Publications 10.1111/cei.12574

[img]
Preview
 Text
cei12574.pdf - Accepted Version
Available under License Publisher holds Copyright.
Download (507kB) | Preview
[img] Text
cei12574.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.
Download (122kB)

There is increasing evidence that the complement system plays an important role in diabetes and the development of diabetic vascular complications. In particular, mannan-binding lectin (MBL) levels are elevated in diabetes patients, and diabetes patients with diabetic nephropathy have higher MBL levels than diabetes patients with normal renal function. The MBL-associated serine proteases (MASPs) MASP-1, MASP-2, and MASP-3, and MBL-associated protein MAp44 have not yet been studied in diabetes patients. We therefore measured plasma levels of MASP-1, MASP-2, MASP-3, and MAp44 in 30 children with type 1 diabetes mellitus (T1DM) and 17 matched control subjects, and in 45 adults with T1DM and 31 matched control subjects. MASP-1 and MASP-2 levels were significantly higher in children and adults with T1DM than in their respective control groups, whereas MASP-3 and MAp44 levels did not differ between patients and controls. MASP-1 and MASP-2 levels correlated with HbA1c, and MASP levels decreased when glycaemic control improved. Since MASP-1 and MASP-2 have been shown to directly interact with blood coagulation, elevated levels of these proteins may play a role in the enhanced thrombotic environment and consequent vascular complications in diabetes.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Experimentelle Hämostase
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Thromboselabor Kinderklinik [discontinued]
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

 Jenny, Lorenz, Schröder, Verena

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 0009-9104

Publisher:

 Blackwell Scientific Publications

Language:

 English

Submitter:

 Verena Zwahlen

Date Deposited:

 29 Apr 2015 12:04

Last Modified:

 05 Dec 2022 14:45

Publisher DOI:

 10.1111/cei.12574

PubMed ID:

 25533914

Uncontrolled Keywords:

 diabetes; mannan-binding lectin-associated serine proteases; MASP-1; MASP-2

BORIS DOI:

 10.7892/boris.67431

URI:

 https://boris.unibe.ch/id/eprint/67431

Actions (login required)

Edit item Edit item
Provide Feedback