Mayer, Alain; Leumann, Christian (2003). A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry. Nucleosides, nucleotides & nucleic acids, 22(10), pp. 1919-1925. Taylor & Francis 10.1081/NCN-120025239
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A novel synthesis of 2'-deoxypseudoisocytidine as well as of its phosphoramidite building block for oligonucleotide synthesis is presented. The synthesis is based on Heck-coupling between N-protected pseudoisocytosine and a silyl protected furanoid glycal. With this procedure the corresponding phosphoramidite building block is obtained in 5 steps and an overall yield of 28%.
Item Type: |
Journal Article (Original Article) |
---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Mayer, Alain, Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1525-7770 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
19 May 2015 09:52 |
Last Modified: |
05 Dec 2022 14:46 |
Publisher DOI: |
10.1081/NCN-120025239 |
PubMed ID: |
14609231 |
Additional Information: |
Notes: Department of Chemistry & Biochemistry, University of Bern, Bern, SwitzerlandFAU - Mayer, Alain |
Uncontrolled Keywords: |
analogs & derivatives Biochemistry chemical synthesis chemistry Deoxycytidine Molecular Structure oligonucleotide phosphoramidite silyl Support,Non-U.S.Gov't synthesis |
BORIS DOI: |
10.7892/boris.68563 |
URI: |
https://boris.unibe.ch/id/eprint/68563 |