Modified natural cycle in vitro fertilization an alternative in vitro fertilization treatment with lower costs per achieved pregnancy but longer treatment time

von Wolff, Michael; Rohner, Susanne; Santi, Alessandro; Stute, Petra; Popovici, Roxana; Weiss, Benedicte (2014). Modified natural cycle in vitro fertilization an alternative in vitro fertilization treatment with lower costs per achieved pregnancy but longer treatment time. Journal of reproductive medicine, 59(11-12), pp. 553-559. Science Printers & Publishers

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OBJECTIVE

To analyze the cost and time requirement per achieved pregnancy in optimized modified natural cycle in vitro fertilization (mNC-IVF) based on a treatment protocol with very few consultations and to compare those with conventional gonadotropin-stimulated aVF (clVF) cycles.

STUDY DESIGN

Mono centric prospective trial. Eighty infertile patients each received 1 modified mNC-IVF cycle using low doses of the clomiphene citrate. Based on the number of consultations and the clinical pregnancy rate per cycle, the total costs and required time to achieve a pregnancy were analyzed and compared with cIVF. Calculations for cIVF were based on standard therapy protocols and outcomes of European registries.

RESULTS

Patients (21-42 years old, 35.4 +/- 4.7 years) undergoing mNC-IVF required on average 1.2 consultations before follicle aspiration. Pregnancy rate per transfer and per initiated cycle were 25% and 13.6%, respectively. Multiple pregnancies did not occur. According to the calculations, total costs per pregnancy rate were around 15% lower with mNC-IVF as compared to cIVF. In contrast, time to achieve an equal pregnancy rate was calculated to take around 30% longer with mNC-IVF as compared to cIVF.

CONCLUSION

mNC-IVF using very low dosages of clomiphene citrate avoids multiple pregnancies and is less expensive but more time consuming per achieved pregnancy when compared to clVF.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
UniBE Contributor:	von Wolff, Michael, Rohner, Susanne, Santi, Alessandro, Stute, Petra
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0024-7758
Publisher:	Science Printers & Publishers
Language:	English
Submitter:	Nathalie Ursula Becher
Date Deposited:	13 May 2015 10:09
Last Modified:	05 Dec 2022 14:47
PubMed ID:	25552127
URI:	https://boris.unibe.ch/id/eprint/68924