Lee, Haur Yueh; Pelivani, Nedzmidin; Beltraminelli, Helmut; Hegyi, Ivan; Yawalkar, Nikhil; Borradori, Luca (2011). Amicrobial pustulosis-like rash in a patient with Crohn's disease under anti-TNF-alpha blocker. Dermatology, 222(4), pp. 304-10. Basel: Karger 10.1159/000329428
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Amicrobial pustulosis of the folds (APF) is a recently described entity characterized by relapsing pustular lesions predominantly involving the cutaneous flexures and scalp. This disease typically occurs in association with systemic lupus erythematosus and a variety of other autoimmune diseases. We here describe an APF-like pustular eruption predominantly affecting the scalp, face and trunk, occurring during long-term infliximab treatment for Crohn's disease. Immunohistochemical staining of skin biopsy specimens for myxovirus resistance protein A, a marker for type 1 interferon-inducible proteins, showed increased staining in the epidermis and dermal mononuclear inflammatory infiltrate. Our observation further extends the spectrum of cutaneous adverse reactions potentially related to anti-tumor necrosis factor-α, the clinical context in which APF can occur as well as its clinical presentations.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Pelivani, Nedzmidin, Beltraminelli, Helmut, Yawalkar, Nikhil, Borradori, Luca |
ISSN: |
1018-8665 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:21 |
Last Modified: |
21 Jun 2023 11:10 |
Publisher DOI: |
10.1159/000329428 |
PubMed ID: |
21757882 |
Web of Science ID: |
000294544200004 |
BORIS DOI: |
10.48350/7045 |
URI: |
https://boris.unibe.ch/id/eprint/7045 (FactScience: 212194) |
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