Stübinger, Stefan; Nuss, Katja; Bürki, Alexander; Mosch, Isabel; le Sidler, Miché; Meikle, Steve T.; von Rechenberg, Brigitte; Santin, Matteo (2015). Osseointegration of titanium implants functionalised with phosphoserine-tethered poly(epsilon-lysine) dendrons: a comparative study with traditional surface treatments in sheep. Journal of materials science - materials in medicine, 26(2), p. 87. Springer 10.1007/s10856-015-5433-3
|
Text
art%3A10.1007%2Fs10856-015-5433-3.pdf - Published Version Available under License Publisher holds Copyright. Download (4MB) | Preview |
The aim of this study was to analyse the osseointegrative potential of phosphoserine-tethered dendrons when applied as surface functionalisation molecules on titanium implants in a sheep model after 2 and 8 weeks of implantation. Uncoated and dendron-coated implants were implanted in six sheep. Sandblasted and etched (SE) or porous additive manufactured (AM) implants with and without additional dendron functionalisation (SE-PSD; AM-PSD) were placed in the pelvic bone. Three implants per group were examined histologically and six implants were tested biomechanically. After 2 and 8 weeks the bone-to-implant contact (BIC) total values of SE implants (43.7 ± 12.2; 53.3 ± 9.0 %) and SE-PSD (46.7 ± 4.5; 61.7 ± 4.9 %) as well as AM implants (20.49 ± 5.1; 43.9 ± 9.7 %) and AM-PSD implants (19.7 ± 3.5; 48.3 ± 15.6 %) showed no statistically significant differences. For SE-PSD and AM-PSD a separate analysis of only the cancellous BIC demonstrated a statistically significant difference after 2 and 8 weeks. Biomechanical findings proved the overall increased stability of the porous implants after 8 weeks. Overall, the great effect of implant macro design on osseointegration was further supported by additional phosphoserine-tethered dendrons for SE and AM implants.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB [discontinued] |
UniBE Contributor: |
Bürki, Alexander |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0957-4530 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Alexander Bürki |
Date Deposited: |
15 Dec 2015 10:21 |
Last Modified: |
05 Dec 2022 14:50 |
Publisher DOI: |
10.1007/s10856-015-5433-3 |
PubMed ID: |
25644101 |
BORIS DOI: |
10.7892/boris.74049 |
URI: |
https://boris.unibe.ch/id/eprint/74049 |
Actions (login required)
 |
Edit item |