Possible dysregulation of cortical plasticity in auditory verbal hallucinations-A cortical thickness study in schizophrenia

van Swam, Claudia; Federspiel, Andrea; Hubl, Daniela; Wiest, Roland; Boesch, Chris; Vermathen, Peter; Kreis, Roland; Strik, Werner; Dierks, Thomas (2012). Possible dysregulation of cortical plasticity in auditory verbal hallucinations-A cortical thickness study in schizophrenia. Journal of psychiatric research, 46(8), pp. 1015-1023. Amsterdam: Elsevier 10.1016/j.jpsychires.2012.03.016

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Investigations of gray matter changes in relation with auditory verbal hallucinations (AVH) have reported conflicting results. Assuming that alterations in gray matter might be related to certain symptoms in schizophrenia this study aimed to investigate changes in cortical thickness specific to AVH. It was hypothesized that schizophrenia patients suffering from persistent AVH would show significant differences in cortical thickness in regions involved in language-production and perception when compared to schizophrenia patients which had never experienced any hallucinations.

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