Subcutaneous perfusion before and during surgery in obese and non-obese patients.

Kaiser, Heiko A.; Kaiser Niedhart, Dagmar Julika; Krejci, Vladimir; Saager, Leif; Erdös, Gabor; Hiltebrand, Luzius B (2015). Subcutaneous perfusion before and during surgery in obese and non-obese patients. Wound repair and regeneration, 24(1), pp. 175-180. Wiley-Blackwell 10.1111/wrr.12389

[img] Text
wrr12389.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (115kB)

Hypoxia at the surgical site impairs wound healing and oxidative killing of microbes. Surgical site infections are more common in obese patients. We hypothesized that subcutaneous oxygen tension (Psq O2 ) would decrease substantially in both obese and non-obese patients following induction of anesthesia and after surgical incision. We performed a prospective observational study that enrolled obese and non-obese surgical patients and measured serial Psq O2 before and during surgery. Seven morbidly obese and seven non-obese patients were enrolled. At baseline breathing room air, Psq O2 values were not significantly different (p=0.66) between obese (6.8 kPa) and non-obese (6.5 kPa) patients. The targeted arterial oxygen tension (40 kPa) was successfully achieved in both groups with an expected significant increase in Psq O2 (obese 16.1 kPa and non-obese 13.4 kPa; p=0.001). After induction of anesthesia and endotracheal intubation, Psq O2 did not change significantly in either cohort in comparison to levels right before induction (obese 15.5, non-obese 13.5 kPa; p=0.95), but decreased significantly during surgery (obese 10.1, non-obese 9.3 kPa; p=0.01). In both morbidly obese and non-obese patients, Psq O2 does not decrease appreciably following induction of anesthesia, but decreases markedly (∼33%) after commencement of surgery. Given the theoretical risks associated with low Psq O2 , future research should investigate how Psq O2 can be maintained after surgical incision. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Kaiser, Heiko Andreas, Kaiser Niedhart, Dagmar Julika, Krejci, Vladimir, Erdoes, Gabor (A)

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1067-1927

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

05 Feb 2016 13:46

Last Modified:

29 Mar 2023 23:34

Publisher DOI:

10.1111/wrr.12389

PubMed ID:

26610062

Uncontrolled Keywords:

Subcutaneous tissue; abdominal surgery; general anesthesia; surgical wound infection

BORIS DOI:

10.7892/boris.76624

URI:

https://boris.unibe.ch/id/eprint/76624

Actions (login required)

Edit item Edit item
Provide Feedback