Schultze-Lutter, F; Debbané, M; Theodoridou, A; Wood, S J; Raballo, A; Michel, C; Schmidt, SJ; Kindler, J; Ruhrmann, S; Uhlhaas, P J (2016). Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets. Frontiers in psychiatry, 7(9), p. 9. Frontiers Media 10.3389/fpsyt.2016.00009
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In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self-experienced expression of the underlying neurobiological aberrations of the disease. Other characteristic symptoms of psychosis (e.g., delusions and hallucinations) were conceptualized as secondary phenomena, resulting from dysfunctional beliefs and suboptimal coping styles with emerging BSs and/or concomitant stressors. While BSs can occur in many mental disorders, in particular affective disorders, a subset of perceptive and cognitive BSs appear to be specific to psychosis and are currently employed in two alternative risk criteria. However, despite their clinical recognition in the early detection of psychosis, neurobiological research on the aetiopathology of psychosis with neuroimaging methods has only just begun to consider the neural correlate of BSs. This perspective paper reviews the emerging evidence of an association between BSs and aberrant brain activation, connectivity patterns, and metabolism, and outlines promising routes for the use of BSs in aetiopathological research on psychosis.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division |
UniBE Contributor: |
Schultze-Lutter, Frauke, Michel, Chantal, Schmidt, Stefanie Julia, Kindler, Jochen |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-0640 |
Publisher: |
Frontiers Media |
Language: |
English |
Submitter: |
Fabienne Bolliger |
Date Deposited: |
27 Apr 2016 11:18 |
Last Modified: |
02 Mar 2023 23:27 |
Publisher DOI: |
10.3389/fpsyt.2016.00009 |
PubMed ID: |
26858660 |
BORIS DOI: |
10.7892/boris.76913 |
URI: |
https://boris.unibe.ch/id/eprint/76913 |
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