Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study

Deschwanden, Alexandra; Karolewicz, Beata; Feyissa, Anteneh M; Treyer, Valerie; Ametamey, Simon M; Johayem, Anass; Burger, Cyrill; Auberson, Yves P; Sovago, Judit; Stockmeier, Craig A; Buck, Alfred; Hasler, Gregor (2011). Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study. American journal of psychiatry, 168(7), pp. 727-34. Washington, D.C.: American Psychiatric Association 10.1176/appi.ajp.2011.09111607

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Clinical and preclinical evidence suggests a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been proposed as an attractive target for novel therapeutic approaches to depression. The goal of this study was to compare mGluR5 binding (in a positron emission tomography [PET] study) and mGluR5 protein expression (in a postmortem study) between individuals with major depressive disorder and psychiatrically healthy comparison subjects.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Healthcare Research
UniBE Contributor:	Hasler, Gregor
ISSN:	0002-953X
Publisher:	American Psychiatric Association
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:22
Last Modified:	05 Dec 2022 14:06
Publisher DOI:	10.1176/appi.ajp.2011.09111607
PubMed ID:	21498461
Web of Science ID:	000292296200013
URI:	https://boris.unibe.ch/id/eprint/7705 (FactScience: 213022)