Benarafa, Charaf (2015). Tumor-induced inflammation alters neutrophil phenotype and disease progression. Breast cancer research, 17(1), p. 135. BioMed Central Ltd. 10.1186/s13058-015-0644-6
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Neutrophils are essential to combat infectious agents but contribute to collateral inflammatory damage. Likewise, neutrophils can kill cancer cells and have been shown to promote malignant growth and metastasis through immunosuppressive functions. Two articles in a recent issue of Nature reveal new mechanisms by which tumors induce changes in neutrophil phenotype through production of inflammatory cytokines. Although the two studies report different outcomes on the effects of neutrophils on tumor growth and metastasis, they delineate novel molecular pathways influencing neutrophil phenotype that may provide new approaches to harnessing neutrophil functions in the treatment of cancer.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Benarafa, Charaf |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1465-5411 |
Publisher: |
BioMed Central Ltd. |
Language: |
English |
Submitter: |
Ursula Zingg-Zünd |
Date Deposited: |
14 Mar 2016 15:00 |
Last Modified: |
05 Dec 2022 14:52 |
Publisher DOI: |
10.1186/s13058-015-0644-6 |
PubMed ID: |
26438048 |
Additional Information: |
Viewpoint |
BORIS DOI: |
10.7892/boris.77350 |
URI: |
https://boris.unibe.ch/id/eprint/77350 |