Predicting 5- and 10-year survival in older women with early-stage breast cancer: self-rated health and walking ability.

Eng, Jessica A; Clough-Gorr, Kerri; Cabral, Howard J; Silliman, Rebecca A (2015). Predicting 5- and 10-year survival in older women with early-stage breast cancer: self-rated health and walking ability. Journal of the American Geriatrics Society, 63(4), pp. 757-762. Wiley-Blackwell 10.1111/jgs.13340

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OBJECTIVES

To determine life expectancy for older women with breast cancer.

DESIGN

Prospective longitudinal study with 10 years of follow-up data.

SETTING

Hospitals or collaborating tumor registries in four geographic regions (Los Angeles, California; Minnesota; North Carolina; Rhode Island).

PARTICIPANTS

Women aged 65 and older at time of breast cancer diagnosis with Stage I to IIIA disease with measures of self-rated health (SRH) and walking ability at baseline (N = 615; 17% aged ≥80, 52% Stage I, 58% with ≥2 comorbidities).

MEASUREMENTS

Baseline SRH, baseline self-reported walking ability, all-cause and breast cancer-specific estimated probability of 5- and 10-year survival.

RESULTS

At the time of breast cancer diagnosis, 39% of women reported poor SRH, and 28% reported limited ability to walk several blocks. The all-cause survival curves appear to separate after approximately 3 years, and the difference in survival probability between those with low SRH and limited walking ability and those with high SRH and no walking ability limitation was significant (0.708 vs 0.855 at 5 years, P ≤ .001; 0.300 vs 0.648 at 10 years, P < .001). There were no differences between the groups in breast cancer-specific survival at 5 and 10 years (P = .66 at 5 years, P = .16 at 10 years).

CONCLUSION

The combination of low SRH and limited ability to walk several blocks at diagnosis is an important predictor of worse all-cause survival at 5 and 10 years. These self-report measures easily assessed in clinical practice may be an effective strategy to improve treatment decision-making in older adults with cancer.

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