Application of Ga(68) -DOTA-exendin-4 PET/CT to localise an occult insulinoma

Cuthbertson, D J; Banks, M; Khoo, B; Antwi, K; Christ, Emanuel; Campbell, F; Raraty, M; Wild, D (2015). Application of Ga(68) -DOTA-exendin-4 PET/CT to localise an occult insulinoma. Clinical endocrinology, 84(5), pp. 789-791. Blackwell Scientific Publications 10.1111/cen.12973

Text cen12973.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

A 49 year old female presented to our Neuroendocrine Tumour (NET) centre with recurrent severe and disabling hypoglycaemia. She had previously been extensively investigated with a clinical and biochemical diagnosis of endogenous hyperinsulinemic hypoglycaemia although the source of hormonal hypersecretion could not be localised with MRI, EUS and (111) In-Octreotide scans. After extensive discussion the patient opted for blind surgical resection undergoing a pylorus-preserving pancreaticoduodenectomy in December 2010. Histological examination of the resected operative specimen demonstrated a normal pancreas with no evidence of neuroendocrine tumour. Consistent with this, post-surgery her hypoglycaemic symptoms persisted with fasting capillary blood glucose of 2.1-6.0 mmol/l with increasing hypoglycaemia unawareness. Consequently she sought alternative clinical opinions from two European Neuroendocrine Tumour Society (ENETS) Centres of Excellence who investigated her collaboratively. This article is protected by copyright. All rights reserved.

Interest & Impact

Downloads

0 since deposited on 31 Mar 2016
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item