van der Meer, Adriaan J; Maan, Raoel; Veldt, Bart J; Feld, Jordan J; Wedemeyer, Heiner; Dufour, Jean-François; Lammert, Frank; Duarte-Rojo, Andres; Manns, Michael P; Zeuzem, Stefan; Peter Hofmann, W; de Knegt, Robert J; Hansen, Bettina E; Janssen, Harry L A (2015). Improvement of platelets after SVR among patients with chronic HCV infection and advanced hepatic fibrosis. Journal of gastroenterology and hepatology, 31(6), pp. 1168-1176. Wiley-Blackwell Publishing Asia 10.1111/jgh.13252
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Improvement of platelets after SVR among patients with chronic HCV infection and advanced hepatic fibrosis..pdf - Accepted Version Available under License Publisher holds Copyright. Download (555kB) | Preview |
BACKGROUND & AIMS
Patients with chronic hepatitis C virus (HCV) infection may develop cirrhosis with portal hypertension, reflected by decreased platelet count and splenomegaly. This retrospective cohort study aimed to assess changes in platelet counts after antiviral therapy among chronic HCV-infected patients with advanced fibrosis.
METHODS
Platelet counts and spleen sizes were recorded in an international cohort of patients with Ishak 4-6 fibrosis who started antiviral therapy between 1990 and 2003. Last measured platelet counts and spleen sizes were compared to their pre-treatment values (within 6 six months prior to the start of therapy). All registered platelet count measurements from 24 week following cessation of antiviral therapy were included in repeated measurement analyses.
RESULTS
This study included 464 patients; 353 (76%) had cirrhosis and 187 (40%) attained sustained virological response (SVR). Among patients with SVR, median platelet count, increased by 35 x10(9) /L (IQR 7-62, p<0.001). In comparison, patients without SVR showed a median decline of 17 x10(9) /L (IQR -5-47, p<0.001). In a subgroup of 209 patients, median decrease in spleen size was 1.0 cm (IQR 0.3-2.0) for patients with SVR, while median spleen size increased with 0.6 cm (IQR -0.1-2.0, p<0.001) among those without SVR. The changes in spleen size and platelet count were significantly correlated (R=-0.41, p<0.001).
CONCLUSIONS
Among chronic HCV-infected patients with advanced hepatic fibrosis the platelet counts improved following SVR and the change in platelets correlated with the change in spleen size following antiviral therapy. These results suggest that HCV eradication leads to reduced portal pressure. This article is protected by copyright. All rights reserved.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie |
UniBE Contributor: |
Dufour, Jean-François |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1440-1746 |
Publisher: |
Wiley-Blackwell Publishing Asia |
Language: |
English |
Submitter: |
Lilian Karin Smith-Wirth |
Date Deposited: |
01 Apr 2016 11:08 |
Last Modified: |
05 Dec 2022 14:53 |
Publisher DOI: |
10.1111/jgh.13252 |
PubMed ID: |
26647353 |
Uncontrolled Keywords: |
Chronic hepatitis C; cirrhosis; platelet count; regression; sustained virological response |
BORIS DOI: |
10.7892/boris.77714 |
URI: |
https://boris.unibe.ch/id/eprint/77714 |
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