Successful prevention of transmission of integrase resistance in the Swiss HIV Cohort Study.

Scherrer, Alexandra U; Yang, Wan-Lin; Kouyos, Roger D; Böni, Jürg; Yerly, Sabine; Klimkait, Thomas; Aubert, Vincent; Cavassini, Matthias; Battegay, Manuel; Hauser, Christoph; Calmy, Alexandra; Schmid, Patrick; Bernasconi, Enos; Günthard, Huldrych F (2016). Successful prevention of transmission of integrase resistance in the Swiss HIV Cohort Study. Journal of infectious diseases, 214(3), pp. 399-402. Oxford University Press 10.1093/infdis/jiw165

[img]
Preview
Text
infdis.jiw165.full.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (865kB) | Preview
[img] Text
infdis.jiw165.full.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (236kB)

Prevalence of integrase inhibitor (INSTI) transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analysed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1,316 (0.1%) drug-naïve samples a major INSTI TDR mutation was detected. Prevalence was stable although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes where more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR affecting a new drug class for years.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Hauser, Christoph Victor

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-1899

Publisher:

Oxford University Press

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

07 Jul 2016 11:14

Last Modified:

02 Mar 2023 23:27

Publisher DOI:

10.1093/infdis/jiw165

PubMed ID:

27130429

BORIS DOI:

10.7892/boris.82117

URI:

https://boris.unibe.ch/id/eprint/82117

Actions (login required)

Edit item Edit item
Provide Feedback