Regulation of fuel metabolism during exercise in hypopituitarism with growth hormone-deficiency (GHD).

Züger, Thomas; Loher, Hannah; Egger, Andrea Alice; Boesch, Christoph Hans; Christ, Emanuel (2016). Regulation of fuel metabolism during exercise in hypopituitarism with growth hormone-deficiency (GHD). Growth hormone & IGF research, 29, pp. 39-44. Elsevier 10.1016/j.ghir.2016.03.007

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OBJECTIVE

Growth hormone (GH) has a strong lipolytic action and its secretion is increased during exercise. Data on fuel metabolism and its hormonal regulation during prolonged exercise in patients with growth hormone deficiency (GHD) is scarce. This study aimed at evaluating the hormonal and metabolic response during aerobic exercise in GHD patients.

DESIGN

Ten patients with confirmed GHD and 10 healthy control individuals (CI) matched for age, sex, BMI, and waist performed a spiroergometric test to determine exercise capacity (VO2max). Throughout a subsequent 120-minute exercise on an ergometer at 50% of individual VO2max free fatty acids (FFA), glucose, GH, cortisol, catecholamines and insulin were measured. Additionally substrate oxidation assessed by indirect calorimetry was determined at begin and end of exercise.

RESULTS

Exercise capacity was lower in GHD compared to CI (VO2max 35.5±7.4 vs 41.5±5.5ml/min∗kg, p=0.05). GH area under the curve (AUC-GH), peak-GH and peak-FFA were lower in GHD patients during exercise compared to CI (AUC-GH 100±93.2 vs 908.6±623.7ng∗min/ml, p<0.001; peak-GH 1.5±1.53 vs 12.57±9.36ng/ml, p<0.001, peak-FFA 1.01±0.43 vs 1.51±0.56mmol/l, p=0.036, respectively). There were no significant differences for insulin, cortisol, catecholamines and glucose. Fat oxidation at the end of exercise was higher in CI compared to GHD patients (295.7±73.9 vs 187.82±103.8kcal/h, p=0.025).

CONCLUSION

A reduced availability of FFA during a 2-hour aerobic exercise and a reduced fat oxidation at the end of exercise may contribute to the decreased exercise capacity in GHD patients. Catecholamines and cortisol do not compensate for the lack of the lipolytic action of GH in patients with GHD.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

UniBE Contributor:

 Züger, Thomas Johannes, Loher, Hannah, Egger, Andrea Alice, Boesch, Christoph Hans, Christ, Emanuel

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1096-6374

Publisher:

 Elsevier

Language:

 English

Submitter:

 Christoph Hans Boesch

Date Deposited:

 06 Jun 2016 11:20

Last Modified:

 02 Mar 2023 23:27

Publisher DOI:

 10.1016/j.ghir.2016.03.007

PubMed ID:

 27084998

Uncontrolled Keywords:

 Endurance capacity; Exercise; Fuel metabolism; Growth hormone deficiency; Lipolysis

BORIS DOI:

 10.7892/boris.82511

URI:

 https://boris.unibe.ch/id/eprint/82511

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