Dobbelaere, D A; Fernandez, P C; Heussler, Volker (2000). Theileria parva: taking control of host cell proliferation and survival mechanisms. Cellular microbiology, 2(2), pp. 91-99. Blackwell 10.1046/j.1462-5822.2000.00045.x
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The intracellular parasite Theileria parva infects and transforms bovine T-cells, inducing their uncontrolled proliferation and spread in non-lymphoid as well as lymphoid tissues. This parasite-induced transformation is the predominant factor contributing to the pathogenesis of a lymphoproliferative disease, called East Coast fever. T. parva-transformed cells become independent of antigenic stimulation or exogenous growth factors. A dissection of the signalling pathways that are activated in T. parva-infected cells shows that the parasite bypasses signalling pathways that normally emanate from the T-cell antigen receptor to induce continuous proliferation. This review concentrates on the influence of the parasite on the state of activation of the mitogen-activated protein kinase (MAPK), NF-kappaB and phosphoinositide-3-kinase (PI3-K) pathways in the host cell. Of the MAPKs, JNK, but not ERK or p38, is active, inducing constitutive activation of the transcription factors AP-1 and ATF-2. A crucial step in the transformation process is the persistent activation of the transcription factor NF-kappaB, which protects T. parva-transformed cells from spontaneous apoptosis accompanying the transformation process. Inhibitor studies also suggest an important role for the lipid kinase, PI-3K, in the continuous proliferation of T. parva-transformed lymphocytes.
Item Type: |
Journal Article (Original Article) |
---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria 08 Faculty of Science > Department of Biology > Institute of Cell Biology |
UniBE Contributor: |
Heussler, Volker |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
1462-5814 |
Publisher: |
Blackwell |
Language: |
English |
Submitter: |
Volker Heussler |
Date Deposited: |
20 Jun 2016 10:39 |
Last Modified: |
05 Dec 2022 14:56 |
Publisher DOI: |
10.1046/j.1462-5822.2000.00045.x |
PubMed ID: |
11207566 |
BORIS DOI: |
10.7892/boris.83744 |
URI: |
https://boris.unibe.ch/id/eprint/83744 |