Ménard, Robert; Heussler, Volker; Yuda, Masao; Nussenzweig, Victor (2008). Plasmodium pre-erythrocytic stages: what's new? Trends in parasitology, 24(12), pp. 564-569. Elsevier Current Trends 10.1016/j.pt.2008.08.009
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The pre-erythrocytic (PE) phase of malaria infection, which extends from injection of sporozoites into the skin to the release of the first generation of merozoites, has traditionally been the 'black box' of the Plasmodium life cycle. However, since the advent of parasite transfection technology 13 years ago, our understanding of the PE phase in cellular and molecular terms has dramatically improved. Here, we review and comment on the major developments in the field in the past five years. Progress has been made in many diverse areas, including identifying and characterizing new proteins of interest, imaging parasites in vivo, understanding better the cell biology of hepatocyte infection and developing new vaccines against PE stages of the parasite.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria 08 Faculty of Science > Department of Biology > Institute of Cell Biology |
UniBE Contributor: |
Heussler, Volker |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
1471-4922 |
Publisher: |
Elsevier Current Trends |
Language: |
English |
Submitter: |
Volker Heussler |
Date Deposited: |
12 Jul 2016 08:15 |
Last Modified: |
05 Dec 2022 14:57 |
Publisher DOI: |
10.1016/j.pt.2008.08.009 |
PubMed ID: |
18929511 |
BORIS DOI: |
10.7892/boris.84083 |
URI: |
https://boris.unibe.ch/id/eprint/84083 |