Ceklic, Lala; Munk, Marion; Wolf-Schnurrbusch, Ute; Gekkieva, Margarita; Wolf, Sebastian (2016). VISUAL ACUITY OUTCOMES OF RANIBIZUMAB TREATMENT IN PATHOLOGIC MYOPIC EYES WITH MACULAR RETINOSCHISIS AND CHOROIDAL NEOVASCULARIZATION. Retina - the journal of retinal and vitreous diseases, 37(4), pp. 687-693. Lippincott, Williams & Wilkins 10.1097/IAE.0000000000001236
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PURPOSE
To investigate visual and morphological outcome in eyes with MRS and choroidal neovascularization (CNV) secondary to pathologic myopia treated with intravitreal (IVT) ranibizumab.
METHODS
Post hoc analysis of the patients included in the RADIANCE trial (n = 277) was performed to evaluate the impact of MRS on the functional outcome in patients with myopic choroidal neovascularization (mCNV) undergoing intravitreal ranibizumab injections.
RESULTS
Prevalence of MRS in pathologic myopia population is 6%. Respective patients were generally older than patients without MRS. Study eyes with MRS at baseline (BL) showed an initially poor treatment response after 3 months (mean change in best corrected visual acuity (BCVA) was 2.8 ± 12.4 letters, P = 0.009). After 12 months of treatment however, the mean change in BCVA was 7.1 ± 14.5 early treatment diabetic retinopathy study (ETDRS) letters (P = 0.025). Patients with MRS at baseline received more intravitreal injections than the other RADIANCE patients without MRS (MRS, n = 15 eyes: 5.8 ± 2.1 vs. RADIANCE non-MRS [n = 207 eyes]: 4.0 ± 2.9; P = 0.0001).
CONCLUSION
Improvement of visual acuity is delayed and reduced after 3 months intravitreal ranibizumab in eyes with MRS and myopic choroidal neovascularization compared to eyes without MRS. More ranibizumab injections are needed in eyes with MRS to gain comparable BCVA at Month 12.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Munk, Marion, Wolf-Schnurrbusch, Ute, Wolf, Sebastian (B) |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0275-004X |
Publisher: |
Lippincott, Williams & Wilkins |
Language: |
English |
Submitter: |
Sebastian Wolf |
Date Deposited: |
29 Aug 2016 10:40 |
Last Modified: |
05 Dec 2022 14:57 |
Publisher DOI: |
10.1097/IAE.0000000000001236 |
PubMed ID: |
27533774 |
BORIS DOI: |
10.7892/boris.86156 |
URI: |
https://boris.unibe.ch/id/eprint/86156 |
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