Gadaldi, Karolina; Feldmeyer, Laurence; Yawalkar, Nikhil; Hunger, Robert (2016). Ingenol Mebutate for Lentigo Maligna: A Case Report. Dermatology, 232 Suppl 1, pp. 24-28. Karger 10.1159/000447393
|
Text
Ingenol Mebutate for Lentigo Maligna - A Case Report.pdf - Published Version Available under License Publisher holds Copyright. Download (528kB) | Preview |
BACKGROUND
Lentigo maligna (LM) is a melanoma in situ on sun-damaged skin, with a strong predilection to the head and neck area of the elderly. Many therapeutic modalities have been proposed in the treatment of this pathology, including surgery, cryotherapy, radiotherapy and topical imiquimod. Up to date surgical excision remains the treatment of choice with the lowest recurrence rate. Recently, a new topical treatment with ingenol mebutate has been described to be efficacious and well tolerated in the treatment of melanoma in situ.
OBJECTIVE
We sought to demonstrate that ingenol mebutate might be an efficacious and well-tolerated treatment in a patient suffering from LM on an aesthetically challenging location.
METHODS
Case report.
RESULTS
After therapeutic failure with imiquimod 5% cream, a new topical treatment with ingenol mebutate gel 0.015% once daily on 3 consecutive days was initiated. Despite visible inflammation, no macroscopic lesion clearance was observed. While the first follow-up using reflectance confocal microscopy (RCM) performed at 6 weeks after the completion of the therapy showed no signs of LM, the second follow-up examination at 12 weeks using RCM and biopsy confirmed recurrence of the lesion.
CONCLUSION
Ingenol mebutate cannot be considered a standard treatment modality for all types of LM. Further studies are needed to evaluate the prerequisites that can ensure therapeutic success.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Gadaldi, Karolina, Feldmeyer, Laurence, Yawalkar, Nikhil, Hunger, Robert |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1018-8665 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Andrea Studer-Gauch |
Date Deposited: |
01 Mar 2017 10:18 |
Last Modified: |
05 Dec 2022 15:01 |
Publisher DOI: |
10.1159/000447393 |
PubMed ID: |
27513527 |
BORIS DOI: |
10.7892/boris.93455 |
URI: |
https://boris.unibe.ch/id/eprint/93455 |
Actions (login required)
 |
Edit item |