Boushell, Margaret K; Hung, Clark T; Hunziker, Ernst Bruno; Strauss, Eric J; Lu, Helen H (2016). Current strategies for integrative cartilage repair. Connective tissue research, 58(5), pp. 393-406. Taylor & Francis 10.1080/03008207.2016.1231180
Full text not available from this repository.Osteoarthritis (OA) is a degenerative joint condition characterized by painful cartilage lesions that impair joint mobility. Current treatments such as lavage, microfracture, and osteochondral implantation fail to integrate newly formed tissue with host tissues and establish a stable transition to subchondral bone. Similarly, tissue-engineered grafts that facilitate cartilage and bone regeneration are challenged by how to integrate the graft seamlessly with surrounding host cartilage and/or bone. This review centers on current approaches to promote cartilage graft integration. It begins with an overview of articular cartilage structure and function, as well as degenerative changes to this relationship attributed to aging, disease, and trauma. A discussion of the current progress in integrative cartilage repair follows, focusing on graft or scaffold design strategies targeting cartilage-cartilage and/or cartilage-bone integration. It is emphasized that integrative repair is required to ensure long-term success of the cartilage graft and preserve the integrity of the newly engineered articular cartilage. Studies involving the use of enzymes, choice of cell source, biomaterial selection, growth factor incorporation, and stratified versus gradient scaffolds are therefore highlighted. Moreover, models that accurately evaluate the ability of cartilage grafts to enhance tissue integrity and prevent ectopic calcification are also discussed. A summary and future directions section concludes the review.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery |
UniBE Contributor: |
Hunziker, Ernst Bruno |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1607-8438 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Romain Perrelet |
Date Deposited: |
07 Feb 2017 07:24 |
Last Modified: |
05 Dec 2022 15:01 |
Publisher DOI: |
10.1080/03008207.2016.1231180 |
PubMed ID: |
27599801 |
Uncontrolled Keywords: |
Bone; cartilage; integration; interface; scaffolds |
URI: |
https://boris.unibe.ch/id/eprint/93930 |
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