Choi, Ryan

Ferreira de Sousa, Maria Cristina; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Choi, Ryan; Hulverson, Matthew A; Arnold, Samuel L M; Van Voorhis, Wesley C; Fan, Erkang; Roberto, Sánchez-Sánchez; Ortega-Mora, Luis M; Hemphill, Andrew (2024). Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice. International journal for parasitology. Drugs and drug resistance, 25, p. 100553. Elsevier 10.1016/j.ijpddr.2024.100553

Anghel, Nicoleta; Imhof, Dennis; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Haenggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo. International journal for parasitology. Drugs and drug resistance, 17, pp. 92-106. Elsevier 10.1016/j.ijpddr.2021.08.007

Sánchez-Sánchez, Roberto; Ferre, Ignacio; Re, Michela; Pérez-Arroyo, Bárbara; Cleofé-Resta, Darío; García, Victor Herrero; Díaz, Manuel Pizarro; Ferrer, Luis Miguel; Ruiz, Hector; Vallejo-García, Raquel; Benavides, Julio; Hulverson, Matthew A; Choi, Ryan; Whitman, Grant R; Hemphill, Andrew; Van Voorhis, Wesley C; Ortega-Mora, Luis Miguel (2021). A short-term treatment with BKI-1294 does not protect foetuses from sheep experimentally infected with Neospora caninum tachyzoites during pregnancy. International journal for parasitology. Drugs and drug resistance, 17, pp. 176-185. Elsevier 10.1016/j.ijpddr.2021.10.001

Imhof, Dennis; Anghel, Nicoleta; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Hänggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts. International journal for parasitology. Drugs and drug resistance, 16, pp. 90-101. Elsevier 10.1016/j.ijpddr.2021.05.001

Van Voorhis, Wesley C; Hulverson, Matthew A; Choi, Ryan; Huang, Wenlin; Arnold, Samuel L M; Schaefer, Deborah A; Betzer, Dana P; Vidadala, Rama S R; Lee, Sangun; Whitman, Grant R; Barrett, Lynn K; Maly, Dustin J; Riggs, Michael W; Fan, Erkang; Kennedy, Thomas J; Tzipori, Saul; Doggett, J Stone; Winzer, Pablo; Anghel, Nicoleta; Imhof, Dennis; ... (2021). One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases. Veterinary parasitology, 289, p. 109336. Elsevier 10.1016/j.vetpar.2020.109336

Anghel, Nicoleta; Winzer, Pablo A.; Imhof, Dennis; Müller, Joachim; Langa, Javier; Rieder, Jessica; Barrett, Lynn K.; Vidadala, Rama Subba Rao; Huang, Wenlin; Choi, Ryan; Hulverson, Mathew A.; Whitman, Grant R.; Arnold, Samuel L.; Van Voorhis, Wesley C.; Ojo, Kayode K.; Maly, Dustin J.; Fan, Erkang; Hemphill, Andrew (2020). Comparative assessment of the effects of bumped kinase inhibitorson early zebrafish embryo development and pregnancy in mice. International journal of antimicrobial agents, 56(3), p. 106099. Elsevier 10.1016/j.ijantimicag.2020.106099

Choi, Ryan; Hulverson, Matthew A; Huang, Wenlin; Vidadala, Rama S R; Whitman, Grant R; Barrett, Lynn K; Schaefer, Deborah A; Betzer, Dana P; Riggs, Michael W; Doggett, J Stone; Hemphill, Andrew; Ortega-Mora, Luis Miguel; McCloskey, Molly C; Arnold, Samuel L M; Hackman, Robert C; Marsh, Kennan C; Lynch, James J; Freiberg, Gail M; Leroy, Bruce E; Kempf, Dale J; ... (2020). Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned. International journal for parasitology, 50(5), pp. 413-422. Elsevier 10.1016/j.ijpara.2020.01.006

Shrestha, Aruna; Ojo, Kayode K; Koston, Florian; Ruttkowski, Bärbel; Vidadala, Rama S R; Dorr, Carlie S; Navaluna, Edelmar D; Whitman, Grant R; Barrett, Kayleigh F; Barrett, Lynn K; Hulverson, Matthew A; Choi, Ryan; Michaels, Samantha A; Maly, Dustin J; Hemphill, Andrew; Van Voorhis, Wesley C; Joachim, Anja (2019). Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro. International journal for parasitology. Drugs and drug resistance, 10, pp. 9-19. Elsevier 10.1016/j.ijpddr.2019.03.004

Sánchez-Sánchez, Roberto; Ferre, Ignacio; Re, Michela; Ramos, Juan José; Regidor-Cerrillo, Javier; Pizarro Díaz, Manuel; González-Huecas, Marta; Tabanera, Enrique; Benavides, Julio; Hemphill, Andrew; Hulverson, Matthew A; Barrett, Lynn K; Choi, Ryan; Whitman, Grant R; Ojo, Kayode K; Van Voorhis, Wesley C; Ortega-Mora, Luis Miguel (2019). Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy. Antimicrobial agents and chemotherapy, 63(7) American Society for Microbiology 10.1128/AAC.02527-18

Sánchez-Sánchez, Roberto; Ferre, Ignacio; Re, Michela; Vázquez, Patricia; Ferrer, Luis Miguel; Blanco-Murcia, Javier; Regidor-Cerrillo, Javier; Pizarro Díaz, Manuel; González-Huecas, Marta; Tabanera, Enrique; García-Lunar, Paula; Benavides, Julio; Castaño, Pablo; Hemphill, Andrew; Hulverson, Matthew A; Whitman, Grant R; Rivas, Kasey L; Choi, Ryan; Ojo, Kayode K; Barrett, Lynn K; ... (2018). Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites. International journal for parasitology. Drugs and drug resistance, 8(1), pp. 112-124. Elsevier 10.1016/j.ijpddr.2018.02.003

Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Schaefer, Deborah A; Hemphill, Andrew; McCloskey, Molly C; Betzer, Dana P; Müller, Joachim; Vidadala, Rama S R; Whitman, Grant R; Rivas, Kasey L; Barrett, Lynn K; Hackman, Robert C; Love, Melissa S; McNamara, Case W; Shaughnessy, Thomas K; Kondratiuk, Alison; Kurnick, Matthew; Banfor, Patricia N; Lynch, James J; ... (2017). Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis. International journal for parasitology, 47(12), pp. 753-763. Elsevier 10.1016/j.ijpara.2017.08.006

Van Voorhis, Wesley C; Doggett, J Stone; Parsons, Marilyn; Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel; Riggs, Michael W; Hemphill, Andrew; Howe, Daniel K; Mealey, Robert H; Lau, Audrey O T; Merritt, Ethan A; Maly, Dustin J; Fan, Erkang; Ojo, Kayode K (2017). Extended-spectrum antiprotozoal bumped kinase inhibitors: A review. Experimental parasitology, 180, pp. 71-83. Elsevier 10.1016/j.exppara.2017.01.001

Müller, Joachim; Aguado Martinez, Adriana; Ortega-Mora, Luis-Miguel; Moreno-Gonzalo, Javier; Ferre, Ignacio; Hulverson, Matthew A; Choi, Ryan; McCloskey, Molly C; Barrett, Lynn K; Maly, Dustin J; Ojo, Kayode K; Van Voorhis, Wes; Hemphill, Andrew (2017). Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis. Journal of antimicrobial chemotherapy, 72(8), pp. 2334-2341. Oxford University Press 10.1093/jac/dkx134