Flatz, Lukas

Nuñez, Nicolas Gonzalo; Berner, Fiamma; Friebel, Ekaterina; Unger, Susanne; Wyss, Nina; Gomez, Julia Martinez; Purde, Mette-Triin; Niederer, Rebekka; Porsch, Maximilian; Lichtensteiger, Christa; Kramer, Rafaela; Erdmann, Michael; Schmitt, Christina; Heinzerling, Lucie; Abdou, Marie-Therese; Karbach, Julia; Schadendorf, Dirk; Zimmer, Lisa; Ugurel, Selma; Klümper, Niklas; ... (2023). Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors. Med (N Y), 4(2), 113-129.e7. Cell Press 10.1016/j.medj.2022.12.007

Sinnberg, Tobias; Lichtensteiger, Christa; Hasan Ali, Omar; Pop, Oltin T; Jochum, Ann-Kristin; Risch, Lorenz; Brugger, Silvio D; Velic, Ana; Bomze, David; Kohler, Philipp; Vernazza, Pietro; Albrich, Werner C; Kahlert, Christian R; Abdou, Maire-Therese; Wyss, Nina; Hofmeister, Kathrin; Niessner, Heike; Zinner, Carl; Gilardi, Mara; Tzankov, Alexandar; ... (2023). Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19. American journal of respiratory and critical care medicine, 207(1), pp. 38-49. American Lung Association 10.1164/rccm.202201-0011OC

Berner, Fiamma; Bomze, David; Lichtensteiger, Christa; Walter, Vincent; Niederer, Rebekka; Hasan Ali, Omar; Wyss, Nina; Bauer, Jens; Freudenmann, Lena Katharina; Marcu, Ana; Wolfschmitt, Eva-Maria; Haen, Sebastian; Gross, Thorben; Abdou, Marie-Therese; Diem, Stefan; Knöpfli, Stella; Sinnberg, Tobias; Hofmeister, Kathrin; Cheng, Hung-Wei; Toma, Marieta; ... (2022). Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade. Science immunology, 7(75), eabn9644. American Association for the Advancement of Science 10.1126/sciimmunol.abn9644

Purde, Mette‑Triin; Niederer, Rebekka; Wagner, ikolaus B.; Diem, Stefan; Berner, Fiamma; Hasan Ali, Omar; Hillmann, Dorothea; Bergamin, Irina; Joerger, Markus; Risch, Martin; Niederhauser, Christoph; Lenz, Tobias L.; Früh, Martin; Risch, Lorenz; Semela, David; Flatz, Lukas (2022). Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients. Journal of cancer research and clinical oncology, 148(3), pp. 647-656. Springer 10.1007/s00432-021-03870-6

Hasan Ali, Omar; Bomze, David; Risch, Lorenz; Brugger, Silvio D; Paprotny, Matthias; Weber, Myriam; Thiel, Sarah; Kern, Lukas; Albrich, Werner C; Kohler, Philipp; Kahlert, Christian R; Vernazza, Pietro; Bühler, Philipp K; Schüpbach, Reto A; Gómez-Mejia, Alejandro; Popa, Alexandra M; Bergthaler, Andreas; Penninger, Josef M; Flatz, Lukas (2021). Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clinical infectious diseases, 73(9), e2869-e2874. Oxford University Press 10.1093/cid/ciaa1496

Ring, Sandra S; Cupovic, Jovana; Onder, Lucas; Lütge, Mechthild; Perez-Shibayama, Christian; Gil-Cruz, Cristina; Scandella, Elke; De Martin, Angelina; Mörbe, Urs; Hartmann, Fabienne; Wenger, Robert; Spiegl, Matthias; Besse, Andrej; Bonilla, Weldy V; Stemeseder, Felix; Schmidt, Sarah; Orlinger, Klaus K; Krebs, Philippe; Ludewig, Burkhard and Flatz, Lukas (2021). Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nature communications, 12(1), p. 4734. Nature Publishing Group 10.1038/s41467-021-25057-w

Cupovic, Jovana; Ring, Sandra S; Onder, Lucas; Colston, Julia M; Lütge, Mechthild; Cheng, Hung-Wei; De Martin, Angelina; Provine, Nicholas M; Flatz, Lukas; Oxenius, Annette; Scandella, Elke; Krebs, Philippe; Engeler, Daniel; Klenerman, Paul; Ludewig, Burkhard (2021). Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8+ T cells. Nature immunology, 22(8), pp. 1042-1051. Nature Publishing Group 10.1038/s41590-021-00969-3

Baron, Rita Christiane; Risch, Lorenz; Weber, Myriam; Thiel, Sarah; Grossmann, Kirsten; Wohlwend, Nadia; Lung, Thomas; Hillmann, Dorothea; Ritzler, Michael; Bigler, Susanna; Egli, Konrad; Ferrara, Francesca; Bodmer, Thomas; Imperiali, Mauro; Heer, Sonja; Renz, Harald; Flatz, Lukas; Kohler, Philipp; Vernazza, Pietro; Kahlert, Christian R; ... (2020). Frequency of serological non-responders and false-negative RT-PCR results in SARS-CoV-2 testing: a population-based study. Clinical chemistry and laboratory medicine, 58(12), pp. 2131-2140. Walter de Gruyter 10.1515/cclm-2020-0978

Gil-Cruz, Cristina; Perez-Shibayama, Christian; De Martin, Angelina; Ronchi, Francesca; van der Borght, Katrien; Niederer, Rebekka; Onder, Lucas; Lütge, Mechthild; Novkovic, Mario; Nindl, Veronika; Ramos, Gustavo; Arnoldini, Markus; Slack, Emma M C; Boivin-Jahns, Valérie; Jahns, Roland; Wyss, Madeleine; Mooser, Catherine; Lambrecht, Bart N; Maeder, Micha T; Rickli, Hans; ... (2019). Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Science, 366(6467), pp. 881-886. American Association for the Advancement of Science 10.1126/science.aav3487

Diem, Stefan; Fässler, Mirjam; Bomze, David; Ali, Omar Hasan; Berner, Fiamma; Niederer, Rebekka; Hillmann, Dorothea; Mangana, Joanna; Levesque, Mitchell P; Dummer, Reinhard; Risch, Lorenz; Recher, Mike; Risch, Martin; Flatz, Lukas (2019). Immunoglobulin G and Subclasses as Potential Biomarkers in Metastatic Melanoma Patients Starting Checkpoint Inhibitor Treatment. Journal of immunotherapy, 42(3), pp. 89-93. Wolters Kluwer Health 10.1097/CJI.0000000000000255

Fässler, Mirjam; Diem, Stefan; Mangana, Joanna; Hasan Ali, Omar; Berner, Fiamma; Bomze, David; Ring, Sandra; Niederer, Rebekka; Del Carmen Gil Cruz, Cristina; Pérez Shibayama, Christian Ivan; Krolik, Michal; Siano, Marco; Joerger, Markus; Recher, Mike; Risch, Lorenz; Güsewell, Sabine; Risch, Martin; Speiser, Daniel E; Ludewig, Burkhard; Levesque, Mitchell P; ... (2019). Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients. Journal for immunotherapy of cancer, 7(1), p. 50. BioMed Central 10.1186/s40425-019-0523-2

Hartwig, Tom; Zwicky, Pascale; Schreiner, Bettina; Yawalkar, Nikhil; Cheng, Phil; Navarini, Alexander; Dummer, Reinhard; Flatz, Lukas; Conrad, Curdin; Schlapbach, Christoph; Becher, Burkhard (2018). Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation. Cell reports, 25(13), 3564-3572.e4. Cell Press 10.1016/j.celrep.2018.12.012

Zürcher, Samuel; Mooser, Catherine; Lüthi, Alexander Urs; Mühlemann, Kathrin; Barbani, Maria Teresa; Mohacsi, Paul; Garzoni, Christian; Gorgievski-Hrisoho, Meri; Schaller, André; Flatz, Lukas (2012). Sensitive and rapid detection of ganciclovir resistance by PCR based MALDI-TOF analysis. Journal of clinical virology, 54(4), pp. 359-63. Amsterdam: Elsevier 10.1016/j.jcv.2012.04.019

Flatz, Lukas; Roychoudhuri, Rahul; Honda, Mitsuo; Filali-Mouhim, Abdelali; Goulet, Jean-Philippe; Kettaf, Nadia; Lin, Min; Roederer, Mario; Haddad, Elias K; Sékaly, Rafick P; Nabel, Gary J (2011). Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 108(14), pp. 5724-9. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.1013084108

Flatz, Lukas; Hegazy, Ahmed N.; Bergthaler, Andreas; Verschoor, Admar; Claus, Christina; Fernandez, Marylise; Gattinoni, Luca; Johnson, Susan; Kreppel, Florian; Kochanek, Stefan; Broek, Maries van den; Radbruch, Andreas; Lévy, Frédéric; Lambert, Paul-Henri; Siegrist, Claire-Anne; Restifo, Nicholas P.; Löhning, Max; Ochsenbein, Adrian F.; Nabel, Gary J. and Pinschewer, Daniel D. (2010). Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity. Nature medicine, 16(3), pp. 339-345. New York, N.Y.: Nature Publishing Group 10.1038/nm.2104

Heikenwalder, Mathias; Prinz, Marco; Zeller, Nicolas; Lang, Karl S; Junt, Tobias; Rossi, Simona; Tumanov, Alexei; Schmidt, Hauke; Priller, Josef; Flatz, Lukas; Rülicke, Thomas; Macpherson, Andrew J; Holländer, Georg A; Nedospasov, Sergei A; Aguzzi, Adriano (2008). Overexpression of lymphotoxin in T cells induces fulminant thymic involution. American journal of pathology, 172(6), pp. 1555-70. New York, N.Y.: Elsevier 10.2353/ajpath.2008.070572