Hediger, Matthias A

Radvanyi, Zsuzsa; Yoo, Eun Jin; Kandasamy, Palanivel; Salas-Bastos, Adrian; Monnerat, Sophie; Refardt, Julie; Christ-Crain, Mirjam; Hayashi, Himeka; Kondo, Yasuhiko; Jantsch, Jonathan; Rubio-Aliaga, Isabel; Sommer, Lukas; Wagner, Carsten A; Hediger, Matthias A; Kwon, Hyug Moo; Loffing, Johannes; Pathare, Ganesh (2024). Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation. The journal of biological chemistry, 300(1), p. 105480. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2023.105480

Tscherrig, Dominic; Bhardwaj, Rajesh; Biner, Daniel; Dernič, Jan; Ross-Kaschitza, Daniela; Peinelt, Christine; Hediger, Matthias A; Lochner, Martin (2024). Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells. Cell calcium, 117, p. 102834. Elsevier 10.1016/j.ceca.2023.102834

Schlosser, Pascal; Scherer, Nora; Grundner-Culemann, Franziska; Monteiro-Martins, Sara; Haug, Stefan; Steinbrenner, Inga; Uluvar, Burulça; Wuttke, Matthias; Cheng, Yurong; Ekici, Arif B; Gyimesi, Gergely; Karoly, Edward D; Kotsis, Fruzsina; Mielke, Johanna; Gomez, Maria F; Yu, Bing; Grams, Morgan E; Coresh, Josef; Boerwinkle, Eric; Köttgen, Michael; ... (2023). Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine. Nature genetics, 55(6), pp. 995-1008. Nature America 10.1038/s41588-023-01409-8

Gyimesi, Gergely; Hediger, Matthias A (2023). Transporter-Mediated Drug Delivery. Molecules, 28(3) MDPI 10.3390/molecules28031151

Sanchez-Collado, Jose; Nieto-Felipe, Joel; Jardin, Isaac; Bhardwaj, Rajesh; Berna-Erro, Alejandro; Salido, Gines M; Smani, Tarik; Hediger, Matthias A; Lopez, Jose J; Rosado, Juan A (2022). Store-Operated Calcium Entry in Breast Cancer Cells Is Insensitive to Orai1 and STIM1 N-Linked Glycosylation. Cancers, 15(1) MDPI AG 10.3390/cancers15010203

Gyimesi, Gergely; Hediger, Matthias A (3 November 2022). Transporter-Mediated Drug Delivery (Preprints). MDPI 10.20944/preprints202211.0062.v1

Lee, Sohyon; Weiss, Tobias; Bühler, Marcel; Mena, Julien; Lottenbach, Zuzanna; Wegmann, Rebekka; Bihl, Michel; Augustynek, Bartlomiej; Baumann, Sven; Goetze, Sandra; van Drogen, Audrey; Vasella, Flavio; Rushing, Elisabeth J; Wollscheid, Bernd; Hediger, Matthias A; Snijder, Berend (7 October 2022). Targeting tumour-intrinsic neural vulnerabilities of glioblastoma (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2022.10.07.511321

Augustynek, Bartlomiej; Gyimesi, Gergely; Dernič, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G; Peinelt, Christine; Hediger, Matthias A; Bhardwaj, Rajesh (2022). Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs. Cell calcium, 105, p. 102616. Elsevier 10.1016/j.ceca.2022.102616

Verouti, Sophia N; Pujol-Giménez, Jonai; Bermudez-Lekerika, Paola; Scherler, Laeticia; Bhardwaj, Rajesh; Thomas, Aurélien; Lenglet, Sébastien; Siegrist, Mark; Hofstetter, Willy; Fuster, Daniel G; Hediger, Matthias A; Escher, Geneviève; Vogt, Bruno (2022). The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance. Frontiers in physiology, 13, p. 912277. Frontiers Research Foundation 10.3389/fphys.2022.912277

Anderegg, Manuel A; Gyimesi, Gergely; Ho, Manh Tin; Hediger, Matthias A; Fuster, Daniel G (2022). The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily—Structure, Function, Regulation and Potential Drug-Target Approaches. Frontiers in physiology, 13, p. 898508. Frontiers Research Foundation 10.3389/fphys.2022.898508

Gyimesi, Gergely; Hediger, Matthias A (2022). Systematic in silico discovery of novel solute carrier-like proteins from proteomes. PLoS ONE, 17(7), e0271062. Public Library of Science 10.1371/journal.pone.0271062

Havukainen, Sami; Pujol-Gimenez, Jonai; Valkonen, Mari; Westerholm-Parvinen, Ann; Hediger, Matthias A; Landowski, Christopher P (2021). Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei. Scientific reports, 11(1), p. 14678. Springer Nature 10.1038/s41598-021-93552-7

Gyimesi, Gergely; Albano, Giuseppe; Fuster, Daniel Guido; Hediger, Matthias A; Pujol Gimenez, Jonai (2019). Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2). Journal of biological chemistry, 294(20), pp. 8046-8063. American Society for Biochemistry and Molecular Biology 10.1074/jbc.RA118.006113

Bürzle, Marc; Hediger, Matthias A (2012). Functional and physiological role of vitamin C transporters. Current topics in membranes, 70, pp. 357-375. San Diego, Calif.: Academic Press 10.1016/B978-0-12-394316-3.00011-9

Kovacs, Gergely; Montalbetti, Nicolas; Simonin, Alexandre; Danko, Tamas; Balazs, Bernadett; Zsembery, Akos; Hediger, Matthias A (2012). Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB). Cell calcium, 52(6), pp. 468-80. Amsterdam: Elsevier 10.1016/j.ceca.2012.08.005

Kovacs, Gergely; Danko, Tamas; Bergeron, Marc J; Balazs, Bernadett; Suzuki, Yoshiro; Zsembery, Akos; Hediger, Matthias A (2011). Heavy metal cations permeate the TRPV6 epithelial cation channel. Cell calcium, 49(1), pp. 43-55. Amsterdam: Elsevier 10.1016/j.ceca.2010.11.007

Landowski, Christopher P; Bolanz, Katrin A; Suzuki, Yoshiro; Hediger, Matthias A (2011). Chemical inhibitors of the calcium entry channel TRPV6. Pharmaceutical research, 28(2), pp. 322-30. New York, N.Y.: Springer US; http://www.springer-ny.com 10.1007/s11095-010-0249-9

Bergeron, Marc J; Bürzle, Marc; Kovacs, Gergely; Simonin, Alexandre; Hediger, Matthias A (2011). Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. Journal of biological chemistry, 286(13), pp. 11242-53. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M110.171728

Dutzler, Raimund; Ernstb, Beat; Hediger, Matthias A; Keppler, Dietrich; Mohr, Peter; Neidhart, Werner; Märki, Hans Peter (2010). Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010. CHIMIA, 64(9), pp. 662-6. Bern: Schweizerische Chemische Gesellschaft

Bolanz, Katrin A; Kovacs, Gergely Gy; Landowski, Christopher P; Hediger, Matthias A (2009). Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Molecular cancer research, 7(12), pp. 2000-10. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1541-7786.MCR-09-0188

Sung, Ji-Min; Cho, Hee-Jung; Yi, Hee; Lee, Chi-Ho; Kim, Hye-Sun; Kim, Dong-Ku; Abd El-Aty, A M; Kim, Jin-Suk; Landowski, Christopher P; Hediger, Matthias A; Shin, Ho-Chul (2008). Characterization of a stem cell population in lung cancer A549 cells. Biochemical and biophysical research communications, 371(1), pp. 163-7. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2008.04.038

Suzuki, Yoshiro; Kovacs, Christopher S; Takanaga, Hitomi; Peng, Ji-Bin; Landowski, Christopher P; Hediger, Matthias A (2008). Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. Journal of bone and mineral research, 23(8), pp. 1249-56. Hoboken, N.J.: Wiley-Blackwell 10.1359/JBMR.080314

Suzuki, Yoshiro; Pasch, Andreas; Bonny, Olivier; Mohaupt, Markus G; Hediger, Matthias A; Frey, Felix J (2008). Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation. Human molecular genetics, 17(11), pp. 1613-8. Oxford: Oxford University Press 10.1093/hmg/ddn048

Bolanz, Katrin A; Hediger, Matthias A; Landowski, Christopher P (2008). The role of TRPV6 in breast carcinogenesis. Molecular cancer therapeutics, 7(2), pp. 271-9. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1535-7163.MCT-07-0478

Mackenzie, Bryan; Illing, Anthony C; Hediger, Matthias A (2008). Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1. American journal of physiology - cell physiology, 294(2), C451-9. Bethesda, Md.: American Physiological Society 10.1152/ajpcell.00439.2007

Suzuki, Yoshiro; Landowski, Christopher P; Hediger, Matthias A (2008). Mechanisms and regulation of epithelial Ca2+ absorption in health and disease. Annual review of physiology, 70, pp. 257-271. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev.physiol.69.031905.161003

Bianco, Suzy D C; Peng, Ji-Bin; Takanaga, Hitomi; Suzuki, Yoshiro; Crescenzi, Alessandra; Kos, Claudine H; Zhuang, Liyan; Freeman, Michael R; Gouveia, Cecilia H A; Wu, Jiangping; Luo, Hongyu; Mauro, Theodora; Brown, Edward M; Hediger, Matthias A (2007). Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. Journal of bone and mineral research, 22(2), pp. 274-85. Hoboken, N.J.: Wiley-Blackwell 10.1359/JBMR.061110

Mackenzie, Bryan; Takanaga, Hitomi; Hubert, Nadia; Rolfs, Andreas; Hediger, Matthias A (2007). Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochemical journal, 403(1), pp. 59-69. London: Portland Press 10.1042/BJ20061290

Konrad, Martin; Schaller, André; Seelow, Dominik; Pandey, Amit Vikram; Waldegger, Siegfried; Lesslauer, Annegret; Vitzthum, Helga; Suzuki, Yoshiro; Luk, John M; Becker, Christian; Schlingmann, Karl P; Schmid, Marcel; Rodriguez-Soriano, Juan; Ariceta, Gema; Cano, Francisco; Enriquez, Ricardo; Juppner, Harald; Bakkaloglu, Sevcan A; Hediger, Matthias A; Gallati, Sabina; ... (2006). Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. American journal of human genetics, 79(5), pp. 949-57. New York, N.Y.: Cell Press 10.1086/508617

Berger, Urs V; Hediger, Matthias A (2006). Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs. Anatomy and embryology, 211(6), pp. 595-606. Berlin: Springer-Verlag 10.1007/s00429-006-0109-x

Mackenzie, Bryan; Ujwal, M L; Chang, Min-Hwang; Romero, Michael F; Hediger, Matthias A (2006). Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes. Pflügers Archiv : European journal of physiology, 451(4), pp. 544-58. Berlin: Springer-Verlag; http://www.springer.de 10.1007/s00424-005-1494-3