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van der Spoel, Evie; van Vliet, Nicolien A; Poortvliet, Rosalinde K E; Du Puy, Robert S; den Elzen, Wendy P J; Quinn, Terence J; Stott, David J; Sattar, Naveed; Kearney, Patricia M; Blum, Manuel R; Alwan, Heba; Rodondi, Nicolas; Collet, Tinh-Hai; Westendorp, Rudi G J; Ballieux, Bart E; Jukema, J Wouter; Dekkers, Olaf M; Gussekloo, Jacobijn; Mooijaart, Simon P and van Heemst, Diana (2024). Incidence and determinants of spontaneous normalization of subclinical hypothyroidism in older adults. The journal of clinical endocrinology and metabolism, 109(3), e1167-e1174. Oxford University Press 10.1210/clinem/dgad623
Steg, P Gabriel; Szarek, Michael; Valgimigli, Marco; Islam, Shahidul; Zeiher, Andreas M; Bhatt, Deepak L; Bittner, Vera A; Chiang, Chern-En; Diaz, Rafael; Goodman, Shaun G; Gotcheva, Nina; Harrington, Robert A; Jukema, J Wouter; Kim, Hyo-Soo; Kim, Sang-Hyun; Morais, Joao; Pordy, Robert; Scemama, Michel; White, Harvey D and Schwartz, Gregory G (2023). Lipoprotein(a) and the Effect of Alirocumab on Revascularization Following Acute Coronary Syndrome. Canadian journal of cardiology, 39(10), pp. 1315-1324. Elsevier 10.1016/j.cjca.2023.04.018
Xu, Yanning; Derakhshan, Arash; Hysaj, Ola; Wildisen, Lea; Ittermann, Till; Pingitore, Alessandro; Abolhassani, Nazanin; Medici, Marco; Kiemeney, Lambertus A L M; Riksen, Niels P; Dullaart, Robin P F; Trompet, Stella; Dörr, Marcus; Brown, Suzanne J; Schmidt, Börge; Führer-Sakel, Dagmar; Vanderpump, Mark P J; Muendlein, Axel; Drexel, Heinz; Fink, Howard A; ... (2023). The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis. The lancet. Diabetes & endocrinology, 11(10), pp. 743-754. Elsevier 10.1016/S2213-8587(23)00227-9
Young, William J; Haessler, Jeffrey; Benjamins, Jan-Walter; Repetto, Linda; Yao, Jie; Isaacs, Aaron; Harper, Andrew R; Ramirez, Julia; Garnier, Sophie; van Duijvenboden, Stefan; Baldassari, Antoine R; Concas, Maria Pina; Duong, ThuyVy; Foco, Luisa; Isaksen, Jonas L; Mei, Hao; Noordam, Raymond; Nursyifa, Casia; Richmond, Anne; Santolalla, Meddly L; ... (2023). Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nature communications, 14(1), p. 1411. Nature Publishing Group 10.1038/s41467-023-36997-w
Lyko, Christina; Blum, Manuel R; Abolhassani, Nazanin; Stuber, Mirah J; Del Giovane, Cinzia; Feller, Martin; Moutzouri, Elisavet; Oberle, Jolanda; Jungo, Katharina T; Collet, Tinh-Hai; den Elzen, Wendy P J; Poortvliet, Rosalinde K E; Du Puy, Robert S; Dekkers, Olaf M; Trompet, Stella; Jukema, J Wouter; Aujesky, Drahomir; Quinn, Terry; Westendorp, Rudi; Kearney, Patricia M; ... (2022). Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials. Journal of internal medicine, 292(6), pp. 892-903. Wiley 10.1111/joim.13544
Alwan, Heba; Villoz, Fanny; Feller, Martin; Dullaart, Robin P F; Bakker, Stephan J L; Peeters, Robin P; Kavousi, Maryam; Bauer, Douglas C; Cappola, Anne R; Yeap, Bu B; Walsh, John P; Brown, Suzanne J; Ceresini, Graziano; Ferrucci, Luigi; Gussekloo, Jacobijn; Trompet, Stella; Iacoviello, Massimo; Moon, Jae Hoon; Razvi, Salman; Benseñor, Isabela M; ... (2022). Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies. European journal of endocrinology, 187(5), S35-S46. BioScientifica Ltd. 10.1530/EJE-22-0523
Young, William J; Lahrouchi, Najim; Isaacs, Aaron; Duong, ThuyVy; Foco, Luisa; Ahmed, Farah; Brody, Jennifer A; Salman, Reem; Noordam, Raymond; Benjamins, Jan-Walter; Haessler, Jeffrey; Lyytikäinen, Leo-Pekka; Repetto, Linda; Concas, Maria Pina; van den Berg, Marten E; Weiss, Stefan; Baldassari, Antoine R; Bartz, Traci M; Cook, James P; Evans, Daniel S; ... (2022). Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nature communications, 13(1), p. 5144. Nature Publishing Group 10.1038/s41467-022-32821-z
Du Puy, Robert S; Poortvliet, Rosalinde K E; Mooijaart, Simon P; Stott, David J; Quinn, Terry; Sattar, Naveed; Westendorp, Rudi G J; Kearney, Patricia M; McCarthy, Vera J C; Byrne, Stephen; Rodondi, Nicolas; Baretella, Oliver; Collet, Tinh-Hai; van Heemst, Diana; Dekkers, Olaf M; Jukema, J Wouter; Smit, Johannes W A; Gussekloo, Jacobijn; den Elzen, Wendy P J (2022). No effect of levothyroxine on hemoglobin in older adults with subclinical hypothyroidism: pooled results from two RCTs. Journal of clinical endocrinology and metabolism, 107(6), e2339-e2347. Endocrine Society 10.1210/clinem/dgac106
Syrogiannouli, Lamprini; Wildisen, Lea; Meuwese, Christiaan; Bauer, Douglas C; Cappola, Anne R; Gussekloo, Jacobijn; den Elzen, Wendy P J; Trompet, Stella; Westendorp, Rudi G J; Jukema, J Wouter; Ferrucci, Luigi; Ceresini, Graziano; Åsvold, Bjørn O; Chaker, Layal; Peeters, Robin P; Imaizumi, Misa; Ohishi, Waka; Vaes, Bert; Völzke, Henry; Sgarbi, Josè A; ... (2022). Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies. Frontiers in psychiatry, 13, p. 774251. Frontiers 10.3389/fpsyt.2022.774251
van Vliet, Nicolien A; van Heemst, Diana; Almeida, Osvaldo P; Åsvold, Bjørn O; Aubert, Carole E.; Bae, Jong Bin; Barnes, Linda E; Bauer, Douglas C; Blauw, Gerard J; Brayne, Carol; Cappola, Anne R; Ceresini, Graziano; Comijs, Hannie C; Dartigues, Jean-Francois; Degryse, Jean-Marie; Dullaart, Robin P F; van Eersel, Marlise E A; den Elzen, Wendy P J; Ferrucci, Luigi; Fink, Howard A; ... (2021). Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis. JAMA Internal Medicine, 181(11), pp. 1440-1450. American Medical Association 10.1001/jamainternmed.2021.5078
Zijlstra, Laurien E; Jukema, J Wouter; Westendorp, Rudi G J; Du Puy, Robert S; Poortvliet, Rosalinde K E; Kearney, Patricia M; O'Keeffe, Linda; Dekkers, Olaf M; Blum, Manuel R.; Rodondi, Nicolas; Collet, Tinh-Hai; Quinn, Terence J; Sattar, Naveed; Stott, David J; Trompet, Stella; den Elzen, Wendy P J; Gussekloo, Jacobijn; Mooijaart, Simon P (2021). Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials. Frontiers in endocrinology, 12, p. 674841. Frontiers Research Foundation 10.3389/fendo.2021.674841
Wildisen, Lea; Del Giovane, Cinzia; Moutzouri, Elisavet; Beglinger, Shanthi; Syrogiannouli, Lamprini; Collet, Tinh-Hai; Cappola, Anne R; Åsvold, Bjørn O; Bakker, Stephan J L; Yeap, Bu B; Almeida, Osvaldo P; Ceresini, Graziano; Dullaart, Robin P F; Ferrucci, Luigi; Grabe, Hans; Jukema, J Wouter; Nauck, Matthias; Trompet, Stella; Völzke, Henry; Westendorp, Rudi; ... (2020). An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms. Scientific Reports, 10(1), p. 19111. Nature Publishing Group 10.1038/s41598-020-75776-1
Jukema, J Wouter; Zijlstra, Laurien E; Bhatt, Deepak L; Bittner, Vera A; Diaz, Rafael; Drexel, Heinz; Goodman, Shaun G; Kim, Yong-Un; Pordy, Robert; Reiner, Zeljko; Roe, Matthew T; Tse, Hung Fat; Valdovinos, Pablo Carlos Montenegro; White, Harvey D; Zeiher, Andreas M; Szarek, Michael; Schwartz, Gregory G; Steg, Philippe Gabriel (2019). Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES. Circulation, 140(25), pp. 2054-2062. American Heart Association 10.1161/CIRCULATIONAHA.119.043826
Clark, David W; Okada, Yukinori; Moore, Kristjan H S; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L K; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M; ... (2019). Associations of autozygosity with a broad range of human phenotypes. Nature communications, 10(1), p. 4957. Nature Publishing Group 10.1038/s41467-019-12283-6
Mooijaart, Simon P; Du Puy, Robert S; Stott, David J; Kearney, Patricia M; Rodondi, Nicolas; Westendorp, Rudi G J; den Elzen, Wendy P J; Postmus, Iris; Poortvliet, Rosalinde K E; van Heemst, Diana; van Munster, Barbara C; Peeters, Robin P; Ford, Ian; Kean, Sharon; Messow, Claudia-Martina; Blum, Manuel R; Collet, Tinh-Hai; Watt, Torquil; Dekkers, Olaf M; Jukema, J Wouter; ... (2019). Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism. JAMA - the journal of the American Medical Association, 322(20), pp. 1977-86. American Medical Association 10.1001/jama.2019.17274
Wildisen, Lea; Moutzouri, Elisavet; Beglinger, Shanthi; Syrogiannouli, Lamprini; Cappola, Anne R; Åsvold, Bjørn O; Bakker, Stephan J L; Ceresini, Graziano; Dullaart, Robin; Ferrucci, Luigi; Grabe, Hans; Jukema, J Wouter; Nauck, Matthias; Trompet, Stella; Völzke, Henry; Westendorp, Rudi G J; Gussekloo, Jacobijn; Peeters, Robin P; Klöppel, Stefan; Aujesky, Drahomir; ... (2019). Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies. BMJ open, 9(7), e029716. BMJ Publishing Group 10.1136/bmjopen-2019-029716
Meuwese, Christiaan L; van Diepen, Merel; Cappola, Anne R; Sarnak, Mark J; Shlipak, Michael G; Bauer, Douglas C; Fried, Linda P; Iacoviello, Massimo; Vaes, Bert; Degryse, Jean; Khaw, Kay-Tee; Luben, Robert N; Åsvold, Bjørn O; Bjøro, Trine; Vatten, Lars J; de Craen, Anton J M; Trompet, Stella; Iervasi, Giorgio; Molinaro, Sabrina; Ceresini, Graziano; ... (2019). Low thyroid function is not associated with an accelerated deterioration in renal function. Nephrology, dialysis, transplantation, 34(4), pp. 650-659. Oxford University Press 10.1093/ndt/gfy071
Sabater-Lleal, Maria; Huffman, Jennifer E; de Vries, Paul S; Marten, Jonathan; Mastrangelo, Michael A; Song, Ci; Pankratz, Nathan; Ward-Caviness, Cavin K; Yanek, Lisa R; Trompet, Stella; Delgado, Graciela E; Guo, Xiuqing; Bartz, Traci M; Martinez-Perez, Angel; Germain, Marine; de Haan, Hugoline G; Ozel, Ayse B; Polasek, Ozren; Smith, Albert V; Eicher, John D; ... (2019). Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels. Circulation, 139(5), pp. 620-635. Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.118.034532
Franceschini, Nora; Giambartolomei, Claudia; de Vries, Paul S; Finan, Chris; Bis, Joshua C; Huntley, Rachael P; Lovering, Ruth C; Tajuddin, Salman M; Winkler, Thomas W; Graff, Misa; Kavousi, Maryam; Dale, Caroline; Smith, Albert V; Hofer, Edith; van Leeuwen, Elisabeth M; Nolte, Ilja M; Lu, Lingyi; Scholz, Markus; Sargurupremraj, Muralidharan; Pitkänen, Niina; ... (2018). GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature communications, 9(1), p. 5141. Nature Publishing Group 10.1038/s41467-018-07340-5
Ligthart, Symen; Vaez, Ahmad; Võsa, Urmo; Stathopoulou, Maria G; de Vries, Paul S; Prins, Bram P; Van der Most, Peter J; Tanaka, Toshiko; Naderi, Elnaz; Rose, Lynda M; Wu, Ying; Karlsson, Robert; Barbalic, Maja; Lin, Honghuang; Pool, René; Zhu, Gu; Macé, Aurélien; Sidore, Carlo; Trompet, Stella; Mangino, Massimo; ... (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American journal of human genetics, 103(5), pp. 691-706. Cell Press 10.1016/j.ajhg.2018.09.009
Wopereis, Daisy M; Du Puy, Robert S; van Heemst, Diana; Walsh, John P; Bremner, Alexandra; Bakker, Stephan J L; Bauer, Douglas C; Cappola, Anne R; Ceresini, Graziano; Degryse, Jean; Dullaart, Robin P F; Feller, Martin; Ferrucci, Luigi; Floriani, Carmen; Franco, Oscar H; Iacoviello, Massimo; Iervasi, Georgio; Imaizumi, Misa; Jukema, J Wouter; Khaw, Kay-Tee; ... (2018). The relation between thyroid function and anemia: a pooled analysis of individual participant data. Journal of clinical endocrinology and metabolism, 103(10), pp. 3658-3667. Endocrine Society 10.1210/jc.2018-00481
Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael; ... (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature genetics, 50(10), pp. 1412-1425. Nature America 10.1038/s41588-018-0205-x
O Riordan, David; Aubert, Carole Elodie; Walsh, Kieran A; van Dorland, Anette; Rodondi, Nicolas; Du Puy, Robert S; Poortvliet, Rosalinde K E; Gussekloo, Jacobijn; Sinnott, Carol; Byrne, Stephen; Galvin, Rose; Jukema, J Wouter; Mooijaart, Simon P; Baumgartner, Christine; McCarthy, Vera; Walsh, Elaine K; Collet, Tinh-Hai; Dekkers, Olaf M; Blum, Manuel R and Kearney, Patricia M (2018). Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study. BMJ open, 8(3), e019003. BMJ Publishing Group 10.1136/bmjopen-2017-019003
Stott, David J; Rodondi, Nicolas; Kearney, Patricia M; Ford, Ian; Westendorp, Rudi G J; Mooijaart, Simon P; Sattar, Naveed; Aubert, Carole E; Aujesky, Drahomir; Bauer, Douglas C; Baumgartner, Christine; Blum, Manuel R; Browne, John P; Byrne, Stephen; Collet, Tinh-Hai; Dekkers, Olaf M; den Elzen, Wendy P J; Du Puy, Robert S; Ellis, Graham; Feller, Martin; ... (2017). Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. New England journal of medicine NEJM, 376(26), pp. 2534-2544. Massachusetts Medical Society MMS 10.1056/NEJMoa1603825
Stott, David J; Gussekloo, Jacobijn; Kearney, Patricia M; Rodondi, Nicolas; Westendorp, Rudi G J; Mooijaart, Simon; Kean, Sharon; Quinn, Terence J; Sattar, Naveed; Hendry, Kirsty; Du Puy, Robert; Den Elzen, Wendy P J; Poortvliet, Rosalinde K E; Smit, Jan W A; Jukema, J Wouter; Dekkers, Olaf M; Blum, Manuel; Collet, Tinh-Hai; McCarthy, Vera; Hurley, Caroline; ... (2017). Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST). BMC Endocrine Disorders, 17(1), p. 6. BioMed Central 10.1186/s12902-017-0156-8
Adams, Hieab H H; Hibar, Derrek P; Chouraki, Vincent; Stein, Jason L; Nyquist, Paul A; Rentería, Miguel E; Trompet, Stella; Arias-Vasquez, Alejandro; Seshadri, Sudha; Desrivières, Sylvane; Beecham, Ashley H; Jahanshad, Neda; Wittfeld, Katharina; Van der Lee, Sven J; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S; ... (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature neuroscience, 19(12), pp. 1569-1582. Nature America 10.1038/nn.4398
Chaker, Layal; Baumgartner, Christine; den Elzen, Wendy P J; Collet, Tinh-Hai; Ikram, M Arfan; Blum, Manuel; Dehghan, Abbas; Drechsler, Christiane; Luben, Robert N; Portegies, Marileen L P; Iervasi, Giorgio; Medici, Marco; Stott, David J; Dullaart, Robin P; Ford, Ian; Bremner, Alexandra; Newman, Anne B; Wanner, Christoph; Sgarbi, José A; Dörr, Marcus; ... (2016). Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis. The Journal of clinical endocrinology and metabolism, 101(11), pp. 4270-4282. The Endocrine Society 10.1210/jc.2016-2255
Pattaro, Cristian; Teumer, Alexander; Gorski, Mathias; Chu, Audrey Y; Li, Man; Mijatovic, Vladan; Garnaas, Maija; Tin, Adrienne; Sorice, Rossella; Li, Yong; Taliun, Daniel; Olden, Matthias; Foster, Meredith; Yang, Qiong; Chen, Ming-Huei; Pers, Tune H; Johnson, Andrew D; Ko, Yi-An; Fuchsberger, Christian; Tayo, Bamidele; ... (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature communications, 7, p. 10023. Nature Publishing Group 10.1038/ncomms10023
Blum, Manuel; Wijsman, Liselotte W; Virgini, Vanessa S; Bauer, Douglas C; den Elzen, Wendy P J; Jukema, J Wouter; Buckley, Brendan M; de Craen, Anton J M; Kearney, Patricia M; Stott, David J; Gussekloo, Jacobjin; Westendorp, Rudi G J; Mooijaart, Simon P; Rodondi, Nicolas (2016). Subclinical Thyroid Dysfunction and Depressive Symptoms among Elderly: A Prospective Cohort Study. Neuroendocrinology, 103(3-4), pp. 291-299. Karger 10.1159/000437387
Chaker, Layal; Baumgartner, Christine; den Elzen, Wendy P J; Ikram, M Arfan; Blum, Manuel; Collet, Tinh-Hai; Bakker, Stephan J L; Dehghan, Abbas; Drechsler, Christiane; Luben, Robert N; Hofman, Albert; Portegies, Marileen L P; Medici, Marco; Iervasi, Giorgio; Stott, David J; Ford, Ian; Bremner, Alexandra; Wanner, Christoph; Ferrucci, Luigi; Newman, Anne B; ... (2015). Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. Journal of clinical endocrinology and metabolism, 100(6), pp. 2181-2191. Endocrine Society 10.1210/jc.2015-1438
Lubitz, Steven A; Lunetta, Kathryn L; Lin, Honghuang; Arking, Dan E; Trompet, Stella; Li, Guo; Krijthe, Bouwe P; Chasman, Daniel I; Barnard, John; Kleber, Marcus E; Dörr, Marcus; Ozaki, Kouichi; Smith, Albert V; Müller-Nurasyid, Martina; Walter, Stefan; Agarwal, Sunil K; Bis, Joshua C; Brody, Jennifer A; Chen, Lin Y; Everett, Brendan M; ... (2014). Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. Journal of the American College of Cardiology, 63(12), pp. 1200-1210. Elsevier 10.1016/j.jacc.2013.12.015
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Nanchen, David; Stott, David J; Gussekloo, Jacobijn; Mooijaart, Simon P; Westendorp, Rudi G J; Jukema, J Wouter; Macfarlane, Peter W; Cornuz, Jacques; Rodondi, Nicolas; Buckley, Brendan M; Ford, Ian; Sattar, Naveed; de Craen, Anton J M; PROSPER Group, (2013). Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study. European journal of heart failure, 15(5), pp. 581-8. Oxford: Oxford University Press 10.1093/eurjhf/hfs195
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