Leppert, David

Oechtering, Johanna; Stein, Kerstin; Schaedelin, Sabine A; Maceski, Aleksandra M; Orleth, Annette; Meier, Stephanie; Willemse, Eline; Qureshi, Ferhan; Heijnen, Ingmar; Regeniter, Axel; Derfuss, Tobias; Benkert, Pascal; D'Souza, Marcus; Limberg, Marguerite; Fischer-Barnicol, Bettina; Achtnichts, Lutz; Mueller, Stefanie; Salmen, Anke; Lalive, Patrice H; Bridel, Claire; ... (2024). Complement Activation Is Associated With Disease Severity in Multiple Sclerosis. Neurology: Neuroimmunology and Neuroinflammation, 11(2), e200212. Wolters Kluwer Health 10.1212/NXI.0000000000200212

Cagol, Alessandro; Benkert, Pascal; Melie-Garcia, Lester; Schaedelin, Sabine A.; Leber, Selina; Tsagkas, Charidimos; Barakovic, Muhamed; Galbusera, Riccardo; Lu, Po-Jui; Weigel, Matthias; Ruberte, Esther; Radue, Ernst-Wilhelm; Yaldizli, Özgür; Oechtering, Johanna; Lorscheider, Johannes; D'Souza, Marcus; Fischer-Barnicol, Bettina; Müller, Stefanie; Achtnichts, Lutz; Vehoff, Jochen; ... (2024). Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS. Neurology, 102(1) Wolters Kluwer Health 10.1212/WNL.0000000000207768

Abdelhak, Ahmed; Benkert, Pascal; Schaedelin, Sabine; Boscardin, W John; Cordano, Christian; Oechtering, Johanna; Ananth, Kirtana; Granziera, Cristina; Melie-Garcia, Lester; Montes, Shivany Condor; Beaudry-Richard, Alexandra; Achtnichts, Lutz; Oertel, Frederike C; Lalive, Patrice H; Leppert, David; Müller, Stefanie; Henry, Roland G; Pot, Caroline; Matthias, Amandine; Salmen, Anke; ... (2023). Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis. JAMA neurology, 80(12), pp. 1317-1325. American Medical Association 10.1001/jamaneurol.2023.3997

Todea, Alexandra Ramona; Melie-Garcia, Lester; Barakovic, Muhamed; Cagol, Alessandro; Rahmanzadeh, Reza; Galbusera, Riccardo; Lu, Po-Jui; Weigel, Matthias; Ruberte, Esther; Radue, Ernst-Wilhelm; Schaedelin, Sabine; Benkert, Pascal; Oezguer, Yaldizli; Sinnecker, Tim; Müller, Stefanie; Achtnichts, Lutz; Vehoff, Jochen; Disanto, Giulio; Findling, Oliver; Chan, Andrew; ... (2023). A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients. Journal of magnetic resonance imaging, 58(3), pp. 864-876. Wiley Interscience 10.1002/jmri.28618

Meier, Stephanie; Willemse, Eline A J; Schaedelin, Sabine; Oechtering, Johanna; Lorscheider, Johannes; Melie-Garcia, Lester; Cagol, Alessandro; Barakovic, Muhamed; Galbusera, Riccardo; Subramaniam, Suvitha; Barro, Christian; Abdelhak, Ahmed; Thebault, Simon; Achtnichts, Lutz; Lalive, Patrice; Müller, Stefanie; Pot, Caroline; Salmen, Anke; Disanto, Giulio; Zecca, Chiara; ... (2023). Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis. JAMA neurology, 80(3), pp. 287-297. American Medical Association 10.1001/jamaneurol.2022.5250

Le, Ngoc Dung; Steinfort, Marel; Grandgirard, Denis; Maleska, Aleksandra; Leppert, David; Kuhle, Jens; Leib, Stephen L (2022). The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis. Scientific reports, 12(1), p. 12945. Springer Nature 10.1038/s41598-022-17282-0

Cagol, Alessandro; Schaedelin, Sabine; Barakovic, Muhamed; Benkert, Pascal; Todea, Ramona-Alexandra; Rahmanzadeh, Reza; Galbusera, Riccardo; Lu, Po-Jui; Weigel, Matthias; Melie-Garcia, Lester; Ruberte, Esther; Siebenborn, Nina; Battaglini, Marco; Radue, Ernst-Wilhelm; Yaldizli, Özgür; Oechtering, Johanna; Sinnecker, Tim; Lorscheider, Johannes; Fischer-Barnicol, Bettina; Müller, Stefanie; ... (2022). Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis. JAMA neurology, 79(7), pp. 682-692. American Medical Association 10.1001/jamaneurol.2022.1025

Oechtering, Johanna; Lincke, Therese; Schaedelin, Sabine; Décard, Bernhard F; Maceski, Aleksandra; Orleth, Annette; Meier, Stephanie; Willemse, Eline; Buchmann, Arabella; Khalil, Michael; Derfuss, Tobias; Benkert, Pascal; Heijnen, Ingmar; Regeniter, Axel; Müller, Stefanie; Achtnichts, Lutz; Lalive, Patrice; Salmen, Anke; Pot, Caroline; Gobbi, Claudio; ... (2022). Intrathecal IgM synthesis is associated with spinal cord manifestation and neuronal injury in early MS. Annals of neurology, 91(6), pp. 814-820. Wiley 10.1002/ana.26348

Polymeris, Alexandros A.; Helfenstein, Fabrice; Benkert, Pascal; Aeschbacher, Stefanie; Leppert, David; Coslovsky, Michael; Willemse, Eline; Schaedelin, Sabine; Blum, Manuel R.; Rodondi, Nicolas; Reichlin, Tobias; Moschovitis, Giorgio; Wuerfel, Jens; De Marchis, Gian Marco; Engelter, Stefan T.; Lyrer, Philippe A.; Conen, David; Kühne, Michael; Osswald, Stefan; Bonati, Leo H.; ... (2022). Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation. Frontiers in neuroscience, 16, p. 819010. Frontiers Research Foundation 10.3389/fnins.2022.819010

Benkert, Pascal; Meier, Stephanie; Schaedelin, Sabine; Manouchehrinia, Ali; Yaldizli, Özgür; Maceski, Aleksandra; Oechtering, Johanna; Achtnichts, Lutz; Conen, David; Derfuss, Tobias; Lalive, Patrice H; Mueller, Christian; Müller, Stefanie; Naegelin, Yvonne; Oksenberg, Jorge R; Pot, Caroline; Salmen, Anke; Willemse, Eline; Kockum, Ingrid; Blennow, Kaj; ... (2022). Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study. The lancet. Neurology, 21(3), pp. 246-257. Elsevier 10.1016/S1474-4422(22)00009-6

Hirzel, Cédric; Grandgirard, Denis; Surial, Bernard; Wider, Manon F.; Leppert, David; Kuhle, Jens; Walti, Laura N.; Schefold, Joerg C.; Spinetti, Thibaud; Suter-Riniker, Franziska; Dijkman, Ronald; Leib, Stephen L (2022). Neuro-axonal injury in COVID-19: the role of systemic inflammation and SARS-CoV-2 specific immune response. Therapeutic advances in neurological disorders, 15, p. 17562864221080528. Sage 10.1177/17562864221080528

Oechtering, Johanna; Schaedelin, Sabine; Benkert, Pascal; Müller, Stefanie; Achtnichts, Lutz; Vehoff, Jochen; Disanto, Giulio; Findling, Oliver; Fischer-Barnicol, Bettina; Orleth, Annette; Chan, Andrew; Pot, Caroline; Barakovic, Muhamed; Rahmanzadeh, Reza; Galbusera, Riccardo; Heijnen, Ingmar; Lalive, Patrice H; Wuerfel, Jens; Subramaniam, Suvitha; Aeschbacher, Stefanie; ... (2021). Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis. Annals of neurology, 90(3), pp. 477-489. Wiley-Blackwell 10.1002/ana.26137

Le, Ngoc Dung; Muri, Lukas; Grandgirard, Denis; Kuhle, Jens; Leppert, David; Leib, Stephen L. (2020). Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis. Journal of neuroinflammation, 17(1), p. 293. BioMed Central 10.1186/s12974-020-01966-3

Muri, Lukas Kilian; Leppert, David; Grandgirard, Denis; Leib, Stephen (2019). MMPs and ADAMs in neurological infectious diseases and multiple sclerosis. Cellular and molecular life sciences : CMLS, 76(16), pp. 3097-3116. Springer 10.1007/s00018-019-03174-6

Disanto, Giulio; Barro, Christian; Benkert, Pascal; Naegelin, Yvonne; Schädelin, Sabine; Giardiello, Antonella; Zecca, Chiara; Blennow, Kaj; Zetterberg, Henrik; Leppert, David; Kappos, Ludwig; Gobbi, Claudio; Kuhle, Jens (2017). Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis. Annals of neurology, 81(6), pp. 857-870. Wiley-Blackwell 10.1002/ana.24954

Liechti, Fabian D; Bächtold, Fabian; Grandgirard, Denis; Leppert, David; Leib, Stephen (2015). The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis. Journal of neuroinflammation, 12(43), p. 43. BioMed Central 10.1186/s12974-015-0257-0

Liechti, Fabian D; Grandgirard, Denis; Leppert, David; Leib, Stephen (2014). Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infection and immunity, 82(4), pp. 1710-1718. American Society for Microbiology 10.1128/IAI.00073-14

Coimbra, Roney S.; Voisin, Veronique; de Saizieu, Antoine B.; Lindberg, Raija L. P.; Wittwer, Matthias; Leppert, David; Leib, Stephen L. (2006). Gene expression in cortex and hippocampus during acute pneumococcal meningitis. BMC biology, 4, p. 15. London: BioMed Central 10.1186/1741-7007-4-15

Williams, Paul L; Leib, Stephen; Kamberi, Perparim; Leppert, David; Sobel, Raymond A; Bifrare, Yoeng-Delphine; Clemons, Karl V; Stevens, David A (2002). Levels of matrix metalloproteinase-9 within cerebrospinal fluid in a rabbit model of coccidioidal meningitis and vasculitis. Journal of infectious diseases, 186(11), pp. 1692-1695. The University of Chicago Press 10.1086/345365

Leppert, David; Lindberg, Raija L.P.; Kappos, Ludwig; Leib, Stephen L. (2001). Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis. Brain research reviews, 36(2-3), pp. 249-257. Elsevier 10.1016/S0165-0173(01)00101-1

Leib, Stephen L.; Clements, John M.; Lindberg, Raija L. P.; Heimgartner, Chris; Loeffler, Jutta M.; Pfister, Luz-Andrea; Täuber, Martin G.; Leppert, David (2001). Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain, 124(9), pp. 1734-1742. Oxford: Oxford University Press 10.1093/brain/124.9.1734

Auer, Marc; Pfister, Luz-Andrea; Leppert, David; Täuber, Martin G.; Leib, Stephen L. (2000). Effects of clinically used antioxidants in experimental pneumococcal meningitis. Journal of infectious diseases, 182(1), pp. 347-350. Cary, N.C.: The University of Chicago Press 10.1086/315658

Leib, Stephen L.; Leppert, David; Clements, John; Täuber, Martin G. (2000). Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis. Infection and immunity, 68(2), pp. 615-620. New York, N.Y.: American Society for Microbiology 10.1128/IAI.68.2.615-620.2000

Leppert, David; Leib, Stephen L.; Grygar, C.; Miller, K. M.; Schaad, U. B.; Holländer, G. A. (2000). Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clinical infectious diseases, 31(1), pp. 80-84. The University of Chicago Press 10.1086/313922