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Preti, Barbara; Suchankova, Anna; Deganutti, Giuseppe; Leuenberger, Michele; Barkan, Kerry; Manulak, Iga; Huang, Xianglin; Carvalho, Sabrina; Ladds, Graham; Lochner, Martin (2022). Discovery and Structure-Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists. Journal of medicinal chemistry, 65(21), pp. 14864-14890. American Chemical Society 10.1021/acs.jmedchem.2c01414
Wall, Mark J; Hill, Emily; Huckstepp, Robert; Barkan, Kerry; Deganutti, Giuseppe; Leuenberger, Michele; Preti, Barbara; Winfield, Ian; Carvalho, Sabrina; Suchankova, Anna; Wei, Haifeng; Safitri, Dewi; Huang, Xianglin; Imlach, Wendy; La Mache, Circe; Dean, Eve; Hume, Cherise; Hayward, Stephanie; Oliver, Jess; Zhao, Fei-Yue; ... (2022). Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression. Nature communications, 13(1), p. 4150. Nature Publishing Group 10.1038/s41467-022-31652-2
Leuenberger, Michele; Häusler, Stephanie; Höhn, Vera; Euler, Adriana; Stieger, Bruno; Lochner, Martin (2021). Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters. Journal of pharmacology and experimental therapeutics, 377(3), pp. 346-357. American Society for Pharmacology and Experimental Therapeutics 10.1124/jpet.120.000449
Deganutti, Giuseppe; Barkan, Kerry; Preti, Barbara; Leuenberger, Michele; Wall, Mark; Frenguelli, Bruno G.; Lochner, Martin; Ladds, Graham; Reynolds, Christopher A. (2021). Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor. ACS pharmacology & translational science, 4(1), pp. 314-326. ACS Publications 10.1021/acsptsci.0c00195
Knight, Anthony; Hemmings, Jennifer L.; Winfield, Ian; Leuenberger, Michele; Frattini, Eugenia; Frenguelli, Bruno G.; Dowell, Simon J.; Lochner, Martin; Ladds, Graham (2020). Correction to Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. Journal of medicinal chemistry, 63(18), p. 10531. American Chemical Society 10.1021/acs.jmedchem.0c01416
Jack, Thomas; Leuenberger, Michele; Ruepp, Marc-David; Vernekar, Sanjeev Kumar V; Thompson, Andrew James; Braga-Lagache, Sophie; Heller, Manfred; Lochner, Martin (2019). Mapping the Orthosteric Binding Site of the Human 5-HT3 Receptor Using Photo-crosslinking Antagonists. ACS chemical neuroscience, 10(1), pp. 438-450. American Chemical Society 10.1021/acschemneuro.8b00327
Ruepp, Marc-David; Wei, Hao; Leuenberger, Michele; Lochner, Martin; Thompson, Andrew James (2017). The binding orientation of structurally-related ligands can differ; A cautionary note. Neuropharmacology, 119, pp. 48-61. Elsevier 10.1016/j.neuropharm.2017.01.023
Leuenberger, Michele; Ritler, Andreas; Simonin, Alexandre; Hediger, Matthias; Lochner, Martin (2016). Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes. ACS chemical neuroscience, 7(5), pp. 534-539. American Chemical Society 10.1021/acschemneuro.5b00311
Knight, Anthony; Hemmings, Jennifer Luise; Winfield, Ian; Leuenberger, Michele; Frattini, Eugenia; Frenguelli, Bruno G.; Dowell, Simon J.; Lochner, Martin; Ladds, Graham (2016). Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. Journal of medicinal chemistry, 59(3), pp. 947-964. American Chemical Society 10.1021/acs.jmedchem.5b01402
Hofer, Alexandre; Kovacs, Gergely; Zappatini, Anna; Leuenberger, Michele; Hediger, Matthias A.; Lochner, Martin (2013). Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorganic & medicinal chemistry, 21(11), pp. 3202-3213. Elsevier 10.1016/j.bmc.2013.03.037
Kanai, Yoshikatsu; Clemençon, Benjamin; Simonin, Alexandre; Leuenberger, Michele; Lochner, Martin; Weisstanner, Martin; Hediger, Matthias A. (2013). The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular aspects of medicine, 34(2-3), pp. 108-120. Elsevier 10.1016/j.mam.2013.01.001
Preti, Barbara; Suchankova, Anna; Barkan, Kerry; Leuenberger, Michele; Ladds, Graham; Lochner, Martin (July 2021). Structure-activity relationship study to find novel potent and selective adenosine A1 receptor agonists [MC-125]. CHIMIA, 75(7/8), p. 667. Schweizerische Chemische Gesellschaft
Preti, Barbara; Leuenberger, Michele; Lochner, Martin (25 August 2020). Synthesis and characterization of an adenosine A1 receptor agonist with non-opioid analgesic properties based on Galpha signaling bias [MC-014]. CHIMIA, 74(7/8), p. 594. Schweizerische Chemische Gesellschaft
Leuenberger, Michele; Bernhard, Stephanie; Grossenbacher, Philipp; Stieger, Bruno; Lochner, Martin (6 September 2019). Synthesis of Fluorescent Tools to Better Understand the Canalicular Lipid Transporter System. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft
Preti, Barbara; Leuenberger, Michele; Lochner, Martin; Frenguelli, Bruno G.; Ladds, Graham (6 September 2019). Development of Molecular Tools for the Cellular Study of Adenosine A1 Receptors. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft
Lochner, Martin; Leuenberger, Michele; Preti, Barbara; Tesfazghi, Bereket; Bartlome, Pascal; Frenguelli, Bruno G.; Barkan-Bulman, Kerry; Ladds, Graham (10 September 2018). Development of Molecular Tools for the Study of Adenosine A1 Receptors (Unpublished). In: 7th RSC/SCI Symposium on GPCRs in Medicinal Chemistry. Verona. 10.-12.09.2018.
Preti, Barbara; Tesfazghi, Bereket; Bartlome, Pascal; Leuenberger, Michele; Frenguelli, Bruno G.; Ladds, Graham; Lochner, Martin (7 September 2018). Molecular Tools for the Cellular Study of Adenosine A1 Receptors. CHIMIA, 72(7/8). Schweizerische Chemische Gesellschaft
Leuenberger, Michele; Bernhard, Stephanie; Stieger, Bruno; Lochner, Martin (21 August 2017). Fluorescent Bile Salt Derivatives for the Investigation of the Canalicular Lipid Transporter System. CHIMIA, 71(7/8). Schweizerische Chemische Gesellschaft
Lochner, Martin; Hemmings, Jennifer Luise; Leuenberger, Michele; Meyer, Jonas; Bartlome, Pascal; Perozzo, Alyssa Victoria; Frenguelli, Bruno G.; Winfield, Ian; Ladds, Graham (12 February 2017). Molecular Tools for the Cellular Study of Adenosine A1 Receptors (Unpublished). In: GDCh/SCS conference on Frontiers in Medicinal Chemistry. Bern. 12.-15.02.2017.
Leuenberger, Michele; Lochner, Martin; Bernhard, Stephanie; Stieger, Bruno (12 February 2017). Synthesis of Fluorescent Bile Salt Derivatives and Their Utility as Tracers of the Canalicular Lipid Transporter System (Unpublished). In: GDCh/SCS conference on Frontiers in Medicinal Chemistry. Bern. 12.-15.2.2017.
Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Leuenberger, Michele; Rüefli, Pascal; Bur-Cecilio Hechavarria, Yamileidi; Ruepp, Marc-David; Thompson, Andrew J. (August 2016). Investigation of the interaction between 5-HT3R and its modulators: progress in understanding the agonist binding site. CHIMIA, 70(7/8), MC121. Schweizerische Chemische Gesellschaft
Leuenberger, Michele; Ritler, Andreas; Aerni, Valerie; Metzger, Simon G.; Ruepp, Marc-David; Lochner, Martin (August 2016). New insights into glutamate transport in brain: Concise asymmetric synthesis of TFB-TBOA and photoaffinity probes. CHIMIA, 70(7/8), MC123. Schweizerische Chemische Gesellschaft
Leuenberger, Michele; Jack, Thomas; Ruepp, Marc-David; Lagache, Sophie; Heller, Manfred; Mühlemann, Oliver; Thompson, Andrew J.; Lochner, Martin (15 June 2015). Synthesis of photo-crosslinking probes and their application for the site-selective chemical modification of the 5-HT3 receptor (Unpublished). In: Challenges in Chemical Biology (ISACS16). Book of Abstracts. ETH Zürich, Hönggerberg, Switzerland. 15.06.-18.06.2015.
Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Ruepp, Marc-David; Leuenberger, Michele; Hemmings, Jennifer Luise; Singhanat, Suradech; Thompson, Andrew James (2 October 2014). Studying Ion Channels and Receptors Using Synthetic Molecular Probes (Unpublished). In: 3rd Swiss-Japanese Chemical Biology Symposium. Bern, Switzerland. 02.-03.10.2014.
Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Leuenberger, Michele; Ruepp, Marc-David; Hemmings, Jennifer Luise; Thompson, Andrew James (20 August 2014). Synthesis of Molecular Tools for the Cellular Study of Ion Channels and Receptors (Unpublished). In: EMBO Conference Chemical Biology. Heidelberg, Germany. 20.-23.08.2014.
Leuenberger, Michele; Lochner, Martin (August 2014). Synthesis of inhibitors and probes for the cellular study of glutamate transporters. CHIMIA, 68(7/8), p. 552. Schweizerische Chemische Gesellschaft
Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Leuenberger, Michele; Hemmings, Jennifer Luise; Singhanat, Suradech (24 January 2014). Toolomics - Molecular Probes for Studying and Modification of Ion Channels and Receptors (Unpublished). In: 12th Swiss Snow Symposium. Saas-Fee, Switzerland. 24.01.2014.
Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Hemmings, Jennifer Luise; Leuenberger, Michele; Ruepp, Marc-David; Thompson, Andrew James (9 June 2013). Synthesis of Molecular Tools for the Cellular Study of Ion Channels and Receptors (Unpublished). In: Gordon Research Conference Bioorganic Chemistry. Andover, NH, USA. 09.-14.06.2013.
Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Hemmings, Jennifer Luise; Leuenberger, Michele; Thompson, Andrew James; Ruepp, Marc-David (26 April 2013). Chemical Tools for the Study and Modification of Ion Channels and Receptors (Unpublished). In: BioChemLig Meeting. Bern. 26.04.2013.
Hofer, Alexandre; Leuenberger, Michele; Kovacs, Gergely; Hediger, Matthias A.; Lochner, Martin (2012). Synthesis of 2-APB analogues as inhibitors of TRPV6-mediated Calcium transport. CHIMIA, 66(7-8), p. 558. Bern: Schweizerische Chemische Gesellschaft
Leuenberger, Michele; Lochner, Martin (2012). Developing chemical tools for the study of transporters. In: Institute of Biochemistry and Molecular Medicine mini-symposium, University of Bern.
Wall, Mark J.; Hill, Emily; Huckstepp, Robert; Barkan, Kerry; Deganutti, Giuseppe; Leuenberger, Michele; Preti, Barbara; Winfield, Ian; Carvalho, Sabrina; Suchankova, Anna; Wei, Haifeng; Safitri, Dewi; Huang, Xianglin; Imlach, Wendy; La Mache, Circe; Dean, Eve; Hume, Cherise; Hayward, Stephanie; Oliver, Jess; Zhao, Fei-Yue; ... (27 April 2022). Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2020.04.04.023945
Deganutti, Giuseppe; Barkan, Kerry; Preti, Barbara; Leuenberger, Michele; Wall, Mark; Frenguelli, Bruno G.; Lochner, Martin; Ladds, Graham; Reynolds, Christopher A. (22 October 2020). Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2020.10.22.350827
