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Bhin, Jinhyuk; Paes Dias, Mariana; Gogola, Ewa; Rolfs, Frank; Piersma, Sander R; de Bruijn, Roebi; de Ruiter, Julian R; van den Broek, Bram; Duarte, Alexandra A; Sol, Wendy; van der Heijden, Ingrid; Andronikou, Christina; Kaiponen, Taina S; Bakker, Lara; Lieftink, Cor; Morris, Ben; Beijersbergen, Roderick L; van de Ven, Marieke; Jimenez, Connie R; Wessels, Lodewyk F A; ... (2023). Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors. Cell reports, 42(5), p. 112538. Cell Press 10.1016/j.celrep.2023.112538
Zingg, Daniel; Bhin, Jinhyuk; Yemelyanenko, Julia; Kas, Sjors M; Rolfs, Frank; Lutz, Catrin; Lee, Jessica K; Klarenbeek, Sjoerd; Silverman, Ian M; Annunziato, Stefano; Chan, Chang S; Piersma, Sander R; Eijkman, Timo; Badoux, Madelon; Gogola, Ewa; Siteur, Bjørn; Sprengers, Justin; de Klein, Bim; de Goeij-de Haas, Richard R; Riedlinger, Gregory M; ... (2022). Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. Nature, 609(7929), E13. Springer Nature 10.1038/s41586-022-05287-8
Zingg, Daniel; Bhin, Jinhyuk; Yemelyanenko, Julia; Kas, Sjors M; Rolfs, Frank; Lutz, Catrin; Lee, Jessica K; Klarenbeek, Sjoerd; Silverman, Ian M; Annunziato, Stefano; Chan, Chang S; Piersma, Sander R; Eijkman, Timo; Badoux, Madelon; Gogola, Ewa; Siteur, Bjørn; Sprengers, Justin; de Klein, Bim; de Goeij-de Haas, Richard R; Riedlinger, Gregory M; ... (2022). Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. Nature, 608(7923), pp. 609-617. Springer Nature 10.1038/s41586-022-05066-5
Widmer, Carmen A; Klebic, Ismar; Domanitskaya, Natalya; Decollogny, Morgane Francine; Howald, Denise; Siffert, Myriam; Essers, Paul; Nowicka, Zuzanna; Stokar-Regenscheit, Nadine; van de Ven, Marieke; de Korte-Grimmerink, Renske; Galván, José A; Pritchard, Colin E.J.; Huijbers, Ivo J; Fendler, Wojciech; Vens, Conchita; Rottenberg, Sven (2022). Loss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy. Cancer research communications, 2(10), pp. 1266-1281. American Association for Cancer Research 10.1158/2767-9764.CRC-22-0208
Paes Dias, Mariana; Tripathi, Vivek; van der Heijden, Ingrid; Cong, Ke; Manolika, Eleni-Maria; Bhin, Jinhyuk; Gogola, Ewa; Galanos, Panagiotis; Annunziato, Stefano; Lieftink, Cor; Andújar-Sánchez, Miguel; Chakrabarty, Synjiban; Smith, Graeme C. M.; van de Ven, Marieke; Beijersbergen, Roderick; Bartkova, Jirina; Rottenberg, Sven; Cantor, Sharon; Bartek, Jiri; Chaudhuri, Arnab Ray; ... (2021). Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps. Molecular cell, 81(22), pp. 4692-4708. Cell Press 10.1016/j.molcel.2021.09.005
Barazas, Marco; Gasparini, Alessia; Huang, Yike; Küçükosmanoğlu, Asli; Annunziato, Stefano; Bouwman, Peter; Sol, Wendy; Kersbergen, Ariena; Proost, Natalie; de Korte-Grimmerink, Renske; van de Ven, Marieke; Jonkers, Jos; Borst, Gerben R; Rottenberg, Sven (2019). Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors. Cancer research, 79(3), pp. 452-460. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-18-2077
Gogola, Ewa; Duarte, Alexandra A; de Ruiter, Julian R; Wiegant, Wouter W; Schmid, Jonas A; de Bruijn, Roebi; James, Dominic I; Guerrero Llobet, Sergi; Vis, Daniel J; Annunziato, Stefano; van den Broek, Bram; Barazas, Marco; Kersbergen, Ariena; van de Ven, Marieke; Tarsounas, Madalena; Ogilvie, Donald J; van Vugt, Marcel; Wessels, Lodewyk F A; Bartkova, Jirina; Gromova, Irina; ... (2018). Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality. Cancer cell, 33(6), 1078-1093.e12. Cell Press 10.1016/j.ccell.2018.05.008
Barazas, Marco; Annunziato, Stefano; Pettitt, Stephen J; de Krijger, Inge; Ghezraoui, Hind; Roobol, Stefan J; Lutz, Catrin; Frankum, Jessica; Song, Fei Fei; Brough, Rachel; Evers, Bastiaan; Gogola, Ewa; Bhin, Jinhyuk; van de Ven, Marieke; van Gent, Dik C; Jacobs, Jacqueline J L; Chapman, Ross; Lord, Christopher J; Jonkers, Jos and Rottenberg, Sven (2018). The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells. Cell reports, 23(7), pp. 2107-2118. Cell Press 10.1016/j.celrep.2018.04.046
Duarte, Alexandra A; Gogola, Ewa; Sachs, Norman; Barazas, Marco; Annunziato, Stefano; R de Ruiter, Julian; Velds, Arno; Blatter, Sohvi Tuulikki; Houthuijzen, Julia M; van de Ven, Marieke; Clevers, Hans; Borst, Piet; Jonkers, Jos; Rottenberg, Sven (2018). BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance. Nature methods, 15(2), pp. 134-140. Nature Publishing Group 10.1038/nmeth.4535
Sachs, Norman; de Ligt, Joep; Kopper, Oded; Gogola, Ewa; Bounova, Gergana; Weeber, Fleur; Balgobind, Anjali Vanita; Wind, Karin; Gracanin, Ana; Begthel, Harry; Korving, Jeroen; van Boxtel, Ruben; Duarte, Alexandra Alves; Lelieveld, Daphne; van Hoeck, Arne; Ernst, Robert Frans; Blokzijl, Francis; Nijman, Isaac Johannes; Hoogstraat, Marlous; van de Ven, Marieke; ... (2018). A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell, 172(1-2), pp. 373-386. Cell Press 10.1016/j.cell.2017.11.010
Rondinelli, Beatrice; Gogola, Ewa; Yücel, Hatice; Duarte, Alexandra A; van de Ven, Marieke; van der Sluijs, Roxanne; Konstantinopoulos, Panagiotis A; Jonkers, Jos; Ceccaldi, Raphaël; Rottenberg, Sven; D'Andrea, Alan D (2017). EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation. Nature cell biology, 19(11), pp. 1371-1378. Nature Publishing Group 10.1038/ncb3626
Drost, Rinske; Dhillon, Kiranjit K; van der Gulden, Hanneke; van der Heijden, Ingrid; Brandsma, Inger; Cruz, Cristina; Chondronasiou, Dafni; Castroviejo-Bermejo, Marta; Boon, Ute; Schut, Eva; van der Burg, Eline; Wientjens, Ellen; Pieterse, Mark; Klijn, Christiaan; Klarenbeek, Sjoerd; Loayza-Puch, Fabricio; Elkon, Ran; van Deemter, Liesbeth; Rottenberg, Sven; van de Ven, Marieke; ... (2016). BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. Journal of clinical investigation, 126(8), pp. 2903-2918. American Society for Clinical Investigation 10.1172/JCI70196
