Yousefi, Shida; Morshed, Md. Mahbubul; Amini, Poorya; Stojkov, Darko; Simon, Dagmar; von Gunten, Stephan; Kaufmann, Thomas; Simon, Hans-Uwe (2015). Basophils exhibit antibacterial activity through extracellular trap formation. Allergy, 70(9), pp. 1184-1188. Wiley-Blackwell 10.1111/all.12662
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Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Yousefi, Shida, Morshed, Md. Mahbubul, Amini, Poorya, Stojkov, Darko, Simon, Dagmar, von Gunten, Stephan, Kaufmann, Thomas (B), Simon, Hans-Uwe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0105-4538 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Debora Scherrer |
Date Deposited: |
11 Sep 2015 08:00 |
Last Modified: |
29 Mar 2023 23:34 |
Publisher DOI: |
10.1111/all.12662 |
PubMed ID: |
26043360 |
Uncontrolled Keywords: |
basophil extracellular trap; basophils; extracellular bacterial killing; innate immunity; phagocytosis |
BORIS DOI: |
10.7892/boris.71497 |
URI: |
https://boris.unibe.ch/id/eprint/71497 |
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