Statistical analysis of the inter-individual variations of the bone shape, volume fraction and fabric and their correlations in the proximal femur

Taghizadeh, Elham; Chandran, Vimal; Reyes, Mauricio; Zysset, Philippe; Büchler, Philippe (2017). Statistical analysis of the inter-individual variations of the bone shape, volume fraction and fabric and their correlations in the proximal femur. Bone, 103, pp. 252-261. Elsevier 10.1016/j.bone.2017.07.012

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Including structural information of trabecular bone improves the prediction of bone strength and fracture risk. However, this information is available in clinical CT scans, only for peripheral bones. We hypothesized that a correlation exists between the shape of the bone, its volume fraction (BV/TV) and fabric, which could be characterized using statistical modeling. High-resolution peripheral computed tomography (HR-pQCT) images of 73 proximal femurs were used to build a combined statistical model of shape, BV/TV and fabric. The model was based on correspondence established by image registration and by morphing of a finite element mesh describing the spatial distribution of the bone properties. Results showed no correlation between the distribution of bone shape, BV/TV and fabric. Only the first mode of variation associated with density and orientation showed a strong relationship (R2 > 0.8). In addition, the model showed that the anisotropic information of the proximal femur does not vary significantly in a population of healthy, osteoporotic and osteopenic samples. In our dataset, the average anisotropy of the population was able to provide a close approximation of the patient-specific anisotropy. These results were confirmed by homogenized finite element (hFE) analyses, which showed that the biomechanical behavior of the proximal femur was not significantly different when the average anisotropic information of the population was used instead of patient-specific fabric extracted from HR-pQCT. Based on these findings, it can be assumed that the fabric information of the proximal femur follows a similar structure in an elderly population of healthy, osteopenic and osteoporotic proximal femurs.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB [discontinued]

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Taghizadeh, Elham; Chandran, Vimal; Reyes, Mauricio; Zysset, Philippe and Büchler, Philippe


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health








PhD Elham Taghizadeh

Date Deposited:

13 Oct 2017 17:04

Last Modified:

01 Nov 2018 02:30

Publisher DOI:


PubMed ID:





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