Association of pre- and early post-transplant serum amino acids and metabolites of amino acids and liver transplant outcome.

Oweira, H; Lahdou, I; Opelz, G; Daniel, V; Terness, P; Schmidt, J; Mehrabi, A; Fusch, G; Schefold, Joerg C.; Zidan, A; Sadeghi, M (2018). Association of pre- and early post-transplant serum amino acids and metabolites of amino acids and liver transplant outcome. Transplant immunology, 46, pp. 42-48. Elsevier 10.1016/j.trim.2017.12.003

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The aim of the present study was to investigate association of serum amino (AA) acids and metabolites of AAs with post-transplant outcome in liver transplant recipients. Eighty-nine patients with end-stage liver diseases and available pre- and early post-transplant serum were characterised as patients with (GI) and without one-year mortality (GII) and patients with and without early graft dysfunction (EAD). A panel of pre- and early post-transplant serum levels of AAs and early and metabolites of tryptophan were measured using tandem mass spectrometry. Patient groups had significantly higher pre-transplant serum levels of phenylalanine, tryptophan, and tryptophan metabolites than healthy controls (for all p<0.001). Pre-transplant serum levels of all these parameters were significantly higher in GI than in GII (for all p<0.001). GI had a higher MELD score and re-transplantation number than GII (p≤0.005 for both investigations). Serum bilirubin on day 5 and serum phenylalanine on day 10 post-transplant were associated parameters of mortality, whereas day 1post-transplant phenylalanine and kynurenine and female gender were associated parameters of EAD. Our results indicate that pre- and early post-transplant levels of phenylalanine, tryptophan and metabolites of tryptophan are increased in patients and are associated with EAD and one-year mortality in liver transplant recipients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Schefold, Joerg C.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0966-3274

Publisher:

Elsevier

Language:

English

Submitter:

Mirella Aeberhard

Date Deposited:

18 Jan 2018 16:38

Last Modified:

24 Oct 2019 02:15

Publisher DOI:

10.1016/j.trim.2017.12.003

PubMed ID:

29258878

Uncontrolled Keywords:

Kynurenic acid Kynurenine Meld Phenylalanine Tryptophan

BORIS DOI:

10.7892/boris.108350

URI:

https://boris.unibe.ch/id/eprint/108350

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