Association of pre- and early post-transplant serum amino acids and metabolites of amino acids and liver transplant outcome.

Oweira, H; Lahdou, I; Opelz, G; Daniel, V; Terness, P; Schmidt, J; Mehrabi, A; Fusch, G; Schefold, Joerg C.; Zidan, A; Sadeghi, M (2018). Association of pre- and early post-transplant serum amino acids and metabolites of amino acids and liver transplant outcome. Transplant immunology, 46, pp. 42-48. Elsevier 10.1016/j.trim.2017.12.003

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Text 2017 - Oweira - Science Direct - PMID 29258878.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (985kB) | Preview

The aim of the present study was to investigate association of serum amino (AA) acids and metabolites of AAs with post-transplant outcome in liver transplant recipients. Eighty-nine patients with end-stage liver diseases and available pre- and early post-transplant serum were characterised as patients with (GI) and without one-year mortality (GII) and patients with and without early graft dysfunction (EAD). A panel of pre- and early post-transplant serum levels of AAs and early and metabolites of tryptophan were measured using tandem mass spectrometry. Patient groups had significantly higher pre-transplant serum levels of phenylalanine, tryptophan, and tryptophan metabolites than healthy controls (for all p<0.001). Pre-transplant serum levels of all these parameters were significantly higher in GI than in GII (for all p<0.001). GI had a higher MELD score and re-transplantation number than GII (p≤0.005 for both investigations). Serum bilirubin on day 5 and serum phenylalanine on day 10 post-transplant were associated parameters of mortality, whereas day 1post-transplant phenylalanine and kynurenine and female gender were associated parameters of EAD. Our results indicate that pre- and early post-transplant levels of phenylalanine, tryptophan and metabolites of tryptophan are increased in patients and are associated with EAD and one-year mortality in liver transplant recipients.

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