Risk Ranking of Antimicrobial-Resistant Hazards Found in Meat in Switzerland.

Collineau, Lucie; Gomes do Carmo, Luis Pedro; Endimiani, Andrea; Magouras, Ioannis; Müntener, Cedric; Schüpbach, Gertraud; Stärk, Katharina D C (2018). Risk Ranking of Antimicrobial-Resistant Hazards Found in Meat in Switzerland. Risk analysis, 38(5), pp. 1070-1084. Blackwell Publishing 10.1111/risa.12901

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Human exposure to bacteria resistant to antimicrobials and transfer of related genes is a complex issue and occurs, among other pathways, via meat consumption. In a context of limited resources, the prioritization of risk management activities is essential. Since the antimicrobial resistance (AMR) situation differs substantially between countries, prioritization should be country specific. The objective of this study was to develop a systematic and transparent framework to rank combinations of bacteria species resistant to selected antimicrobial classes found in meat, based on the risk they represent for public health in Switzerland. A risk assessment model from slaughter to consumption was developed following the Codex Alimentarius guidelines for risk analysis of foodborne AMR. Using data from the Swiss AMR monitoring program, 208 combinations of animal species/bacteria/antimicrobial classes were identified as relevant hazards. Exposure assessment and hazard characterization scores were developed and combined using multicriteria decision analysis. The effect of changing weights of scores was explored with sensitivity analysis. Attributing equal weights to each score, poultry-associated combinations represented the highest risk. In particular, contamination with extended-spectrum β-lactamase/plasmidic AmpC-producing Escherichia coli in poultry meat ranked high for both exposure and hazard characterization. Tetracycline- or macrolide-resistant Enterococcus spp., as well as fluoroquinolone- or macrolide-resistant Campylobacter jejuni, ranked among combinations with the highest risk. This study provides a basis for prioritizing future activities to mitigate the risk associated with foodborne AMR in Switzerland. A user-friendly version of the model was provided to risk managers; it can easily be adjusted to the constantly evolving knowledge on AMR.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Gomes do Carmo, Luis Pedro; Endimiani, Andrea; Magouras, Ioannis and Schüpbach, Gertraud

Subjects:

600 Technology > 630 Agriculture

ISSN:

0272-4332

Publisher:

Blackwell Publishing

Language:

English

Submitter:

Susanne Agnes Lerch

Date Deposited:

22 Feb 2018 15:51

Last Modified:

24 Oct 2019 15:28

Publisher DOI:

10.1111/risa.12901

PubMed ID:

28973821

Uncontrolled Keywords:

Antimicrobial resistance microbiological risk assessment multicriteria decision analysis prioritization

BORIS DOI:

10.7892/boris.110137

URI:

https://boris.unibe.ch/id/eprint/110137

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