Risk Ranking of Antimicrobial-Resistant Hazards Found in Meat in Switzerland.

Collineau, Lucie; Gomes do Carmo, Luis Pedro; Endimiani, Andrea; Magouras, Ioannis; Müntener, Cedric; Schüpbach, Gertraud; Stärk, Katharina D C (2018). Risk Ranking of Antimicrobial-Resistant Hazards Found in Meat in Switzerland. Risk analysis, 38(5), pp. 1070-1084. Blackwell Publishing 10.1111/risa.12901

Text Collineau_et_al-2017-Risk_Analysis.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (575kB) | Request a copy

Human exposure to bacteria resistant to antimicrobials and transfer of related genes is a complex issue and occurs, among other pathways, via meat consumption. In a context of limited resources, the prioritization of risk management activities is essential. Since the antimicrobial resistance (AMR) situation differs substantially between countries, prioritization should be country specific. The objective of this study was to develop a systematic and transparent framework to rank combinations of bacteria species resistant to selected antimicrobial classes found in meat, based on the risk they represent for public health in Switzerland. A risk assessment model from slaughter to consumption was developed following the Codex Alimentarius guidelines for risk analysis of foodborne AMR. Using data from the Swiss AMR monitoring program, 208 combinations of animal species/bacteria/antimicrobial classes were identified as relevant hazards. Exposure assessment and hazard characterization scores were developed and combined using multicriteria decision analysis. The effect of changing weights of scores was explored with sensitivity analysis. Attributing equal weights to each score, poultry-associated combinations represented the highest risk. In particular, contamination with extended-spectrum β-lactamase/plasmidic AmpC-producing Escherichia coli in poultry meat ranked high for both exposure and hazard characterization. Tetracycline- or macrolide-resistant Enterococcus spp., as well as fluoroquinolone- or macrolide-resistant Campylobacter jejuni, ranked among combinations with the highest risk. This study provides a basis for prioritizing future activities to mitigate the risk associated with foodborne AMR in Switzerland. A user-friendly version of the model was provided to risk managers; it can easily be adjusted to the constantly evolving knowledge on AMR.

Interest & Impact

Downloads

1 since deposited on 22 Feb 2018
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item