Tracing and targeting cancer stem cells: New venture for personalized molecular cancer therapy.

Radpour, Ramin (2017). Tracing and targeting cancer stem cells: New venture for personalized molecular cancer therapy. World journal of stem cells, 9(10), pp. 169-178. Baishideng Publishing Group 10.4252/wjsc.v9.i10.169

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Tumors consist of a mixture of heterogeneous cell types. Cancer stem cells (CSCs) are a minor sub-population within the bulk cancer fraction which has been found to reconstitute and propagate the disease and to be frequently resistant to chemotherapy, irradiation, cytotoxic drugs and probably also against immune attack. CSCs are considered as the seeds of tumor recurrence, driving force of tumorigenesis and metastases. This underlines the urgent need for innovative methods to identify and target CSCs. However, the role and existence of CSCs in therapy resistance and cancer recurrence remains a topic of intense debate. The underlying biological properties of the tumor stem cells are extremely dependent on numerous signals, and the targeted inhibition of these stem cell signaling pathways is one of the promising approaches of the new antitumor therapy approaches. This perspective review article summarizes the novel methods of tracing CSCs and discusses the hallmarks of CSC identification influenced by the microenvironment or by having imperfect detection markers. In addition, explains the known molecular mechanisms of therapy resistance in CSCs as reliable and clinically predictive markers that could enable the use of new targeted antitumor therapy in the sense of personalized medicine.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Tumor-Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Tumor-Immunologie

UniBE Contributor:

Radpour, Ramin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1948-0210

Publisher:

Baishideng Publishing Group

Language:

English

Submitter:

Nicole Corminboeuf

Date Deposited:

26 Mar 2018 12:32

Last Modified:

28 Oct 2019 23:45

Publisher DOI:

10.4252/wjsc.v9.i10.169

PubMed ID:

29104735

Uncontrolled Keywords:

Cancer recurrence Cancer stem cells Cancer therapy Chemotherapy Combination therapy Immunotherapy Radiation therapy

BORIS DOI:

10.7892/boris.111297

URI:

https://boris.unibe.ch/id/eprint/111297

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