Small Peptides Able to Suppress Prostaglandin E₂ Generation in Renal Mesangial Cells.

Vasilakaki, Sofia; Pastukhov, Oleksandr; Mavromoustakos, Thomas; Huwiler, Andrea; Kokotos, George (2018). Small Peptides Able to Suppress Prostaglandin E₂ Generation in Renal Mesangial Cells. Molecules, 23(1) Molecular Diversity Preservation International MDPI 10.3390/molecules23010158

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Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE₂ in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhibitor of secreted phospholipase A₂, which has been previously shown to reduce PGE₂ synthesis in rat renal mesangial cells. Among the synthesized compounds, the tripeptide derivative 11 exhibited a nice dose-dependent suppression of PGE₂ production, similar to that observed for GK115.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Huwiler, Andrea

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1420-3049

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Jana Berger

Date Deposited:

21 Mar 2018 10:17

Last Modified:

24 Oct 2019 13:09

Publisher DOI:

10.3390/molecules23010158

PubMed ID:

29342835

Uncontrolled Keywords:

inhibitors mesangial cells peptides prostaglandin E2 secreted phospholipase A2

BORIS DOI:

10.7892/boris.111462

URI:

https://boris.unibe.ch/id/eprint/111462

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