Vasilakaki, Sofia; Pastukhov, Oleksandr; Mavromoustakos, Thomas; Huwiler, Andrea; Kokotos, George (2018). Small Peptides Able to Suppress Prostaglandin E₂ Generation in Renal Mesangial Cells. Molecules, 23(1) Molecular Diversity Preservation International MDPI 10.3390/molecules23010158
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Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE₂ in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhibitor of secreted phospholipase A₂, which has been previously shown to reduce PGE₂ synthesis in rat renal mesangial cells. Among the synthesized compounds, the tripeptide derivative 11 exhibited a nice dose-dependent suppression of PGE₂ production, similar to that observed for GK115.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Huwiler, Andrea |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1420-3049 |
Publisher: |
Molecular Diversity Preservation International MDPI |
Language: |
English |
Submitter: |
Jana Berger |
Date Deposited: |
21 Mar 2018 10:17 |
Last Modified: |
05 Dec 2022 15:10 |
Publisher DOI: |
10.3390/molecules23010158 |
PubMed ID: |
29342835 |
Uncontrolled Keywords: |
inhibitors mesangial cells peptides prostaglandin E2 secreted phospholipase A2 |
BORIS DOI: |
10.7892/boris.111462 |
URI: |
https://boris.unibe.ch/id/eprint/111462 |
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