Novel insights into bat influenza A viruses.

Ciminski, Kevin; Thamamongood, Thiprampai; Zimmer, Gert; Schwemmle, Martin (2017). Novel insights into bat influenza A viruses. Journal of general virology, 98(10), pp. 2393-2400. Society for General Microbiology 10.1099/jgv.0.000927

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In 2012 and 2013, influenza virus genome sequences of two new influenza A virus (IAV) subtypes were discovered in bat specimens, but further characterization was largely impeded by the lack of infectious virus. With the identification of highly susceptible cell lines, reconstitution of infectious bat IAV by reverse genetics recently succeeded and allowed a first insight into the life cycle of these viruses. Although there is a certain degree of functional compatibility between bat and conventional influenza A virus proteins, there are striking differences, including receptor usage, polarity of infection and reassortment potential.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Zimmer, Gert

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

0022-1317

Publisher:

Society for General Microbiology

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

15 May 2018 13:44

Last Modified:

15 May 2018 13:54

Publisher DOI:

10.1099/jgv.0.000927

PubMed ID:

28906230

Uncontrolled Keywords:

bats glycoproteins influenza A viruses packaging reassortment zoonosis

BORIS DOI:

10.7892/boris.112044

URI:

https://boris.unibe.ch/id/eprint/112044

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