Ciminski, Kevin; Thamamongood, Thiprampai; Zimmer, Gert; Schwemmle, Martin (2017). Novel insights into bat influenza A viruses. Journal of general virology, 98(10), pp. 2393-2400. Society for General Microbiology 10.1099/jgv.0.000927
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In 2012 and 2013, influenza virus genome sequences of two new influenza A virus (IAV) subtypes were discovered in bat specimens, but further characterization was largely impeded by the lack of infectious virus. With the identification of highly susceptible cell lines, reconstitution of infectious bat IAV by reverse genetics recently succeeded and allowed a first insight into the life cycle of these viruses. Although there is a certain degree of functional compatibility between bat and conventional influenza A virus proteins, there are striking differences, including receptor usage, polarity of infection and reassortment potential.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Zimmer, Gert |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 630 Agriculture |
ISSN: |
0022-1317 |
Publisher: |
Society for General Microbiology |
Language: |
English |
Submitter: |
Pamela Schumacher |
Date Deposited: |
15 May 2018 13:44 |
Last Modified: |
05 Dec 2022 15:11 |
Publisher DOI: |
10.1099/jgv.0.000927 |
PubMed ID: |
28906230 |
Uncontrolled Keywords: |
bats glycoproteins influenza A viruses packaging reassortment zoonosis |
BORIS DOI: |
10.7892/boris.112044 |
URI: |
https://boris.unibe.ch/id/eprint/112044 |
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